KIAA1462, a coronary artery disease associated gene, is a candidate gene for late onset Alzheimer disease in APOE carriers

Deborah G. Murdock, Yuki Bradford, Nathalie Schnetz-Boutaud, Ping Mayo, Melissa J. Allen, Laura N. D'Aoust, Xueying Liang, Sabrina L. Mitchell, Stephan Zuchner, Gary W. Small, John R. Gilbert, Margaret A. Pericak-Vance, Jonathan L. Haines

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Alzheimer disease (AD) is a devastating neurodegenerative disease affecting more than five million Americans. In this study, we have used updated genetic linkage data from chromosome 10 in combination with expression data from serial analysis of gene expression to choose a new set of thirteen candidate genes for genetic analysis in late onset Alzheimer disease (LOAD). Results in this study identify the KIAA1462 locus as a candidate locus for LOAD in APOE4 carriers. Two genes exist at this locus, KIAA1462, a gene associated with coronary artery disease, and "rokimi", encoding an untranslated spliced RNA The genetic architecture at this locus suggests that the gene product important in this association is either "rokimi", or a different isoform of KIAA1462 than the isoform that is important in cardiovascular disease. Expression data suggests that isoform f of KIAA1462 is a more attractive candidate for association with LOAD in APOE4 carriers than "rokimi" which had no detectable expression in brain.

Original languageEnglish (US)
Article numbere82194
JournalPloS one
Volume8
Issue number12
DOIs
StatePublished - Dec 12 2013

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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