Abstract
A novel therapeutic strategy to prevent or reverse ventricular remodeling, the substrate for heart failure and arrhythmias following a myocardial infarction, is the use of cell-based therapy. Successful cell-based tissue regeneration involves a complex orchestration of cellular and molecular events that include stem cell engraftment and differentiation, secretion of anti-inflammatory and angiogenic mediators, and proliferation of endogenous cardiac stem cells. Recent therapeutic approaches involve bone marrow-derived mononuclear cells and mesenchymal stem cells, adipose tissue-derived stem cells, cardiac-derived stem cells and cell combinations. Clinical trials employing mesenchymal stem cells and cardiac-derived stem cells have demonstrated efficacy in infarct size reduction and regional wall contractility improvement. Regarding delivery methods, the safety of catheter-based, transendocardial stem cell injection has been established. These proof-of-concept studies have paved the way for ongoing pivotal trials. Future studies will focus on determining the most efficacious cell type(s) and/or cell combinations and the mechanisms underlying their therapeutic effects.
| Original language | English |
|---|---|
| Pages (from-to) | 17-24 |
| Number of pages | 8 |
| Journal | Regenerative Medicine |
| Volume | 7 |
| Issue number | 6 SUPPL. |
| DOIs | |
| State | Published - Nov 1 2012 |
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Keywords
- Cardiac stem cell
- Cell transplantation
- Heart failure
- Ischemic heart disease
- Mesenchymal stem cell
- Myocardial infarction
ASJC Scopus subject areas
- Biomedical Engineering
- Embryology
Cite this
Key developments in stem cell therapy in cardiology. / Schulman, Ivonne H; Hare, Joshua.
In: Regenerative Medicine, Vol. 7, No. 6 SUPPL., 01.11.2012, p. 17-24.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Key developments in stem cell therapy in cardiology
AU - Schulman, Ivonne H
AU - Hare, Joshua
PY - 2012/11/1
Y1 - 2012/11/1
N2 - A novel therapeutic strategy to prevent or reverse ventricular remodeling, the substrate for heart failure and arrhythmias following a myocardial infarction, is the use of cell-based therapy. Successful cell-based tissue regeneration involves a complex orchestration of cellular and molecular events that include stem cell engraftment and differentiation, secretion of anti-inflammatory and angiogenic mediators, and proliferation of endogenous cardiac stem cells. Recent therapeutic approaches involve bone marrow-derived mononuclear cells and mesenchymal stem cells, adipose tissue-derived stem cells, cardiac-derived stem cells and cell combinations. Clinical trials employing mesenchymal stem cells and cardiac-derived stem cells have demonstrated efficacy in infarct size reduction and regional wall contractility improvement. Regarding delivery methods, the safety of catheter-based, transendocardial stem cell injection has been established. These proof-of-concept studies have paved the way for ongoing pivotal trials. Future studies will focus on determining the most efficacious cell type(s) and/or cell combinations and the mechanisms underlying their therapeutic effects.
AB - A novel therapeutic strategy to prevent or reverse ventricular remodeling, the substrate for heart failure and arrhythmias following a myocardial infarction, is the use of cell-based therapy. Successful cell-based tissue regeneration involves a complex orchestration of cellular and molecular events that include stem cell engraftment and differentiation, secretion of anti-inflammatory and angiogenic mediators, and proliferation of endogenous cardiac stem cells. Recent therapeutic approaches involve bone marrow-derived mononuclear cells and mesenchymal stem cells, adipose tissue-derived stem cells, cardiac-derived stem cells and cell combinations. Clinical trials employing mesenchymal stem cells and cardiac-derived stem cells have demonstrated efficacy in infarct size reduction and regional wall contractility improvement. Regarding delivery methods, the safety of catheter-based, transendocardial stem cell injection has been established. These proof-of-concept studies have paved the way for ongoing pivotal trials. Future studies will focus on determining the most efficacious cell type(s) and/or cell combinations and the mechanisms underlying their therapeutic effects.
KW - Cardiac stem cell
KW - Cell transplantation
KW - Heart failure
KW - Ischemic heart disease
KW - Mesenchymal stem cell
KW - Myocardial infarction
UR - http://www.scopus.com/inward/record.url?scp=84870685387&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84870685387&partnerID=8YFLogxK
U2 - 10.2217/rme.12.80
DO - 10.2217/rme.12.80
M3 - Article
C2 - 23346572
AN - SCOPUS:84870685387
VL - 7
SP - 17
EP - 24
JO - Regenerative Medicine
JF - Regenerative Medicine
SN - 1746-0751
IS - 6 SUPPL.
ER -