Key developments in stem cell therapy in cardiology

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

A novel therapeutic strategy to prevent or reverse ventricular remodeling, the substrate for heart failure and arrhythmias following a myocardial infarction, is the use of cell-based therapy. Successful cell-based tissue regeneration involves a complex orchestration of cellular and molecular events that include stem cell engraftment and differentiation, secretion of anti-inflammatory and angiogenic mediators, and proliferation of endogenous cardiac stem cells. Recent therapeutic approaches involve bone marrow-derived mononuclear cells and mesenchymal stem cells, adipose tissue-derived stem cells, cardiac-derived stem cells and cell combinations. Clinical trials employing mesenchymal stem cells and cardiac-derived stem cells have demonstrated efficacy in infarct size reduction and regional wall contractility improvement. Regarding delivery methods, the safety of catheter-based, transendocardial stem cell injection has been established. These proof-of-concept studies have paved the way for ongoing pivotal trials. Future studies will focus on determining the most efficacious cell type(s) and/or cell combinations and the mechanisms underlying their therapeutic effects.

Original languageEnglish (US)
Pages (from-to)17-24
Number of pages8
JournalRegenerative Medicine
Volume7
Issue number6 SUPPL.
DOIs
StatePublished - Nov 2012

Keywords

  • Cardiac stem cell
  • Cell transplantation
  • Heart failure
  • Ischemic heart disease
  • Mesenchymal stem cell
  • Myocardial infarction

ASJC Scopus subject areas

  • Biomedical Engineering
  • Embryology

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