Ketoprofen versus indomethacin in patients with acute gouty arthritis

A multicenter, double blind comparative study

Roy D Altman, S. Honig, J. M. Levin, R. W. Lightfoot

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Fifty-nine patients with acute gouty arthritis entered into a 7-day multicenter, double blind trial of ketoprofen versus indomethacin. Patients were randomly assigned to receive 100 mg of ketoprofen (n = 29 patients) or 50 mg of indomethacin (n = 30 patients) 3 times a day. More than 90% of the patients in each group reported pain relief within the 1st day of treatment. By Day 5, 7 patients in the ketoprofen group and 6 in the indomethacin group discontinued treatment because of complete or substantial pain relief. At the end of the study, most patients in both groups were rated as having marked improvement both by the investigators and by self-assessment. Three patients in each group withdrew prematurely because of drug related gastrointestinal disorders. Ketoprofen compared favorably for efficacy and safety with indomethacin in the treatment of gouty arthritis.

Original languageEnglish (US)
Pages (from-to)1422-1426
Number of pages5
JournalJournal of Rheumatology
Volume15
Issue number9
StatePublished - 1988

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Gouty Arthritis
Ketoprofen
Double-Blind Method
Indomethacin
Gastrointestinal Agents
Pain
Therapeutics
Research Personnel
Safety

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Ketoprofen versus indomethacin in patients with acute gouty arthritis : A multicenter, double blind comparative study. / Altman, Roy D; Honig, S.; Levin, J. M.; Lightfoot, R. W.

In: Journal of Rheumatology, Vol. 15, No. 9, 1988, p. 1422-1426.

Research output: Contribution to journalArticle

Altman, Roy D ; Honig, S. ; Levin, J. M. ; Lightfoot, R. W. / Ketoprofen versus indomethacin in patients with acute gouty arthritis : A multicenter, double blind comparative study. In: Journal of Rheumatology. 1988 ; Vol. 15, No. 9. pp. 1422-1426.
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