Ketoconazole-induced sweet syndrome: A new association

Katherine L. Baquerizo Nole, Eric Lee, Gabriel Villada, Paolo Romanelli

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Sweet syndrome (SS) is an acute febrile neutrophilic dermatosis that can be associated with malignancy and medications. A 60-year-old man presented with erythematous, edematous, and ulcerated plaques in the extensor surface of the upper extremities, after a ketoconazole course due to pityrosporum folliculitis. Skin biopsy showed a dense dermal neutrophilic infiltrate, associated with marked papillary dermal edema. Blood count showed leukocytosis and neutrophilia. Skin lesions resolved spontaneously with discoloration after 2 weeks of discontinuation of ketoconazole. Although most cases of drug-induced SS are associated with granulocyte colony-stimulating factor, other medications need to be considered. This is the first reported case of ketoconazole-induced SS despite its widespread use.

Original languageEnglish (US)
Pages (from-to)419-422
Number of pages4
JournalAmerican Journal of Dermatopathology
Volume37
Issue number5
DOIs
StatePublished - 2015

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Keywords

  • ketoconazole
  • neutrophilic dermatosis
  • Sweet syndrome

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Dermatology

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