Many clinical conditions exist in which standard penetrating keratoplasties are at high risk of failure. These situations require alternative interventions including keratoprostheses. The most challenging of this subset of patients to treat are those with corneal blindness due to autoimmune diseases. Studies have suggested that these patients respond poorly to transplantation due to alterations in corneal tissue at the level of the cellular, microbiological, and immunological microenvironments due to the inflammatory nature of autoimmune-related conjunctivitides. A variety of interventions exist for visual rehabilitation in this patient population depending on the severity of the condition. These options range from artificial keratoprostheses, such as the Boston keratoprosthesis type 1 in patients with a lubricated ocular surface, to the biologic keratoprostheses like the modified osteo-odonto keratoprosthesis (MOOKP) in the most severe autoimmune patients. The current literature suggests that in the setting of autoimmune dysfunction, biological keratoprostheses are far superior to their artificial keratoprosthesis alternatives.
|Original language||English (US)|
|Title of host publication||Keratoprostheses and Artificial Corneas|
|Subtitle of host publication||Fundamentals and Surgical Applications|
|Publisher||Springer Berlin Heidelberg|
|Number of pages||8|
|State||Published - Jan 1 2015|
ASJC Scopus subject areas