Keratoacanthomas as a complication of dermal filler injections

Leslie S. Baumann, Paolo Romanelli, Ovidio Marangoni, Lucy K. Martin

Research output: Contribution to journalArticlepeer-review


Keratoacanthomas (KAs) are common squamous neoplasms that originate in the pilosebaceous glands. KAs are considered by some physicians to be well-differentiated squamous cell carcinomas. The exact cause of KAs is unknown; however, they are associated with sun exposure, genetic factors, immunosuppression, carcinogens, viruses, and trauma. Histologically, a KA is characterized by deep, bulbous lobules of keratinizing, well-differentiated squamous epithelium with a keratin-filled central crater. There is marked acanthosis with hyperkeratosis and little or no parakeratosis. Multiple KAs may be classified as the Ferguson-Smith type, the Grzybowski type, and the Witten and Zak type. KAs grow rapidly and, in most cases, resolve spontaneously. Although KAs rarely progress to metastatic carcinoma, early diagnosis and treatment are recommended. In this article, we describe a patient who developed multiple facial KAs after receiving dermal filler injections. The patient responded favorably to treatment with acitretin 50 mg once daily for 1 month. This is a rare presentation of KAs occurring after dermal filler injections.

Original languageEnglish (US)
Pages (from-to)450-452
Number of pages3
JournalCosmetic Dermatology
Issue number7
StatePublished - Jul 1 2007

ASJC Scopus subject areas

  • Surgery
  • Dermatology


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