TY - JOUR
T1 - Karyotype studies on human leukemic lymphoblasts in vitro and as serial transplants in neonatal syrian hamsters
AU - Krishan, Awtar
AU - Raychaudhuri, Ratna
AU - Flowers, Arlene
PY - 1969/12
Y1 - 1969/12
N2 - Human leukemic lymphoblasts (CCRF-CEM) have retained a near-diploid modal chromosome number and extra D-group marker chromosomes through more than 4½ years of growth in continuous suspension cultures. Tumors resulting from implantation of these cells from both frozen stock and continuous cell cultures into neonatal Syrian hamsters, and maintained therein by serial heterotransplantation, gradually evolved into cell populations with near-tetraploid modal chromosome numbers, most members having retained the extra D-group chromosome noticed earlier.
AB - Human leukemic lymphoblasts (CCRF-CEM) have retained a near-diploid modal chromosome number and extra D-group marker chromosomes through more than 4½ years of growth in continuous suspension cultures. Tumors resulting from implantation of these cells from both frozen stock and continuous cell cultures into neonatal Syrian hamsters, and maintained therein by serial heterotransplantation, gradually evolved into cell populations with near-tetraploid modal chromosome numbers, most members having retained the extra D-group chromosome noticed earlier.
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U2 - 10.1093/jnci/43.6.1203
DO - 10.1093/jnci/43.6.1203
M3 - Article
C2 - 5273072
AN - SCOPUS:0014656473
VL - 43
SP - 1203
EP - 1214
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
SN - 0027-8874
IS - 6
ER -