@article{be3f47f01f7b4f878d7dfcfb8f382387,
title = "Karyotype studies on human leukemic lymphoblasts in vitro and as serial transplants in neonatal syrian hamsters",
abstract = "Human leukemic lymphoblasts (CCRF-CEM) have retained a near-diploid modal chromosome number and extra D-group marker chromosomes through more than 4½ years of growth in continuous suspension cultures. Tumors resulting from implantation of these cells from both frozen stock and continuous cell cultures into neonatal Syrian hamsters, and maintained therein by serial heterotransplantation, gradually evolved into cell populations with near-tetraploid modal chromosome numbers, most members having retained the extra D-group chromosome noticed earlier.",
author = "Awtar Krishan and Ratna Raychaudhuri and Arlene Flowers",
note = "Funding Information: 1 Received August 7, 1967, revised August 3, 1969; accepted August II, 1969. 2 These studies were supported in part by Public Health Service research grants CA 6516 from the National Cancer Institute and FR 05526 from the Division of Research Facilities and Resources; and by grants from the Albert and Mary Lasker Foundation, New York, and the Alvin T. and Viola D. Fuller Cancer Research Unit Grant, American Cancer Society, Inc. (Massachusetts Division). 3 We wish to thank Drs. George E. Foley, Richard A. Adams, Betty G. Uzman, and Mr. Herbert Lazarus for their critical suggestions and help; Mr. W. Rapport and Mrs. Patricia Hutchins for photographic and technical assistance, and Miss Eleanor Monkouski for secretarial help.",
year = "1969",
month = dec,
doi = "10.1093/jnci/43.6.1203",
language = "English (US)",
volume = "43",
pages = "1203--1214",
journal = "Journal of the National Cancer Institute",
issn = "0027-8874",
publisher = "Oxford University Press",
number = "6",
}
