Abstract
Culture of KSHV-infected lymphatic endothelial cells in 3D increases viral gene expression, leading to Notch-induced MT1-MMP-dependent endothelial-to- mesenchymal transition. This reproduces patterns of KSHV gene expression and presence of mesenchymal KSHV-infected cells found in KS lesions, narrowing the gap between in vitro systems of infection and KSHV tumorigenesis.
Original language | English (US) |
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Pages (from-to) | 529-531 |
Number of pages | 3 |
Journal | Cell Host and Microbe |
Volume | 10 |
Issue number | 6 |
DOIs | |
State | Published - Dec 15 2011 |
ASJC Scopus subject areas
- Parasitology
- Microbiology
- Virology