Kaposi's sarcoma herpesvirus oncogenesis is a notch better in 3D

Enrique A. Mesri, Ethel Cesarman

Research output: Contribution to journalShort surveypeer-review

4 Scopus citations


Culture of KSHV-infected lymphatic endothelial cells in 3D increases viral gene expression, leading to Notch-induced MT1-MMP-dependent endothelial-to- mesenchymal transition. This reproduces patterns of KSHV gene expression and presence of mesenchymal KSHV-infected cells found in KS lesions, narrowing the gap between in vitro systems of infection and KSHV tumorigenesis.

Original languageEnglish (US)
Pages (from-to)529-531
Number of pages3
JournalCell Host and Microbe
Issue number6
StatePublished - Dec 15 2011

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Virology


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