Kaposi's sarcoma herpesvirus oncogenesis is a notch better in 3D

Enrique A. Mesri; Ethel Cesarman

doi:10.1016/j.chom.2011.11.008

Kaposi's sarcoma herpesvirus oncogenesis is a notch better in 3D

Enrique A. Mesri, Ethel Cesarman

Microbiology & Immunology

Research output: Contribution to journal › Short survey › peer-review

4 Scopus citations

Abstract

Culture of KSHV-infected lymphatic endothelial cells in 3D increases viral gene expression, leading to Notch-induced MT1-MMP-dependent endothelial-to- mesenchymal transition. This reproduces patterns of KSHV gene expression and presence of mesenchymal KSHV-infected cells found in KS lesions, narrowing the gap between in vitro systems of infection and KSHV tumorigenesis.

Original language	English (US)
Pages (from-to)	529-531
Number of pages	3
Journal	Cell Host and Microbe
Volume	10
Issue number	6
DOIs	https://doi.org/10.1016/j.chom.2011.11.008
State	Published - Dec 15 2011

ASJC Scopus subject areas

Parasitology
Microbiology
Virology

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title = "Kaposi's sarcoma herpesvirus oncogenesis is a notch better in 3D",

abstract = "Culture of KSHV-infected lymphatic endothelial cells in 3D increases viral gene expression, leading to Notch-induced MT1-MMP-dependent endothelial-to- mesenchymal transition. This reproduces patterns of KSHV gene expression and presence of mesenchymal KSHV-infected cells found in KS lesions, narrowing the gap between in vitro systems of infection and KSHV tumorigenesis.",

author = "Mesri, {Enrique A.} and Ethel Cesarman",

year = "2011",

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T1 - Kaposi's sarcoma herpesvirus oncogenesis is a notch better in 3D

AU - Mesri, Enrique A.

AU - Cesarman, Ethel

PY - 2011/12/15

Y1 - 2011/12/15

N2 - Culture of KSHV-infected lymphatic endothelial cells in 3D increases viral gene expression, leading to Notch-induced MT1-MMP-dependent endothelial-to- mesenchymal transition. This reproduces patterns of KSHV gene expression and presence of mesenchymal KSHV-infected cells found in KS lesions, narrowing the gap between in vitro systems of infection and KSHV tumorigenesis.

AB - Culture of KSHV-infected lymphatic endothelial cells in 3D increases viral gene expression, leading to Notch-induced MT1-MMP-dependent endothelial-to- mesenchymal transition. This reproduces patterns of KSHV gene expression and presence of mesenchymal KSHV-infected cells found in KS lesions, narrowing the gap between in vitro systems of infection and KSHV tumorigenesis.

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U2 - 10.1016/j.chom.2011.11.008

DO - 10.1016/j.chom.2011.11.008

M3 - Short survey

C2 - 22177556

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JO - Cell Host and Microbe

JF - Cell Host and Microbe

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ER -

Kaposi's sarcoma herpesvirus oncogenesis is a notch better in 3D

Abstract

ASJC Scopus subject areas

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