Kaposi's sarcoma herpesvirus oncogenesis is a notch better in 3D

Enrique A. Mesri; Ethel Cesarman

doi:10.1016/j.chom.2011.11.008

Kaposi's sarcoma herpesvirus oncogenesis is a notch better in 3D

Enrique A. Mesri, Ethel Cesarman

Microbiology & Immunology

Research output: Contribution to journal › Short survey

4 Scopus citations

Abstract

Culture of KSHV-infected lymphatic endothelial cells in 3D increases viral gene expression, leading to Notch-induced MT1-MMP-dependent endothelial-to- mesenchymal transition. This reproduces patterns of KSHV gene expression and presence of mesenchymal KSHV-infected cells found in KS lesions, narrowing the gap between in vitro systems of infection and KSHV tumorigenesis.

Original language	English (US)
Pages (from-to)	529-531
Number of pages	3
Journal	Cell Host and Microbe
Volume	10
Issue number	6
DOIs	https://doi.org/10.1016/j.chom.2011.11.008
State	Published - Dec 15 2011

ASJC Scopus subject areas

Parasitology
Microbiology
Virology

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Mesri, E. A., & Cesarman, E. (2011). Kaposi's sarcoma herpesvirus oncogenesis is a notch better in 3D. Cell Host and Microbe, 10(6), 529-531. https://doi.org/10.1016/j.chom.2011.11.008

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abstract = "Culture of KSHV-infected lymphatic endothelial cells in 3D increases viral gene expression, leading to Notch-induced MT1-MMP-dependent endothelial-to- mesenchymal transition. This reproduces patterns of KSHV gene expression and presence of mesenchymal KSHV-infected cells found in KS lesions, narrowing the gap between in vitro systems of infection and KSHV tumorigenesis.",

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AU - Cesarman, Ethel

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AB - Culture of KSHV-infected lymphatic endothelial cells in 3D increases viral gene expression, leading to Notch-induced MT1-MMP-dependent endothelial-to- mesenchymal transition. This reproduces patterns of KSHV gene expression and presence of mesenchymal KSHV-infected cells found in KS lesions, narrowing the gap between in vitro systems of infection and KSHV tumorigenesis.

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