Kaposi's sarcoma and its associated herpesvirus

Enrique A. Mesri; Ethel Cesarman; Chris Boshoff

doi:10.1038/nrc2888

Kaposi's sarcoma and its associated herpesvirus

Enrique A. Mesri, Ethel Cesarman, Chris Boshoff

Microbiology & Immunology

Research output: Contribution to journal › Review article › peer-review

487 Scopus citations

Abstract

Kaposi's sarcoma (KS) is the most common cancer in HIV-infected untreated individuals. Kaposi's sarcoma-associated herpesvirus (KSHV; also known as human herpesvirus 8 (HHV8)) is the infectious cause of this neoplasm. In this Review we describe the epidemiology of KS and KSHV, and the insights into the remarkable mechanisms through which KSHV can induce KS that have been gained in the past 16 years. KSHV latent transcripts, such as latency-associated nuclear antigen (LANA), viral cyclin, viral FLIP and viral-encoded microRNAs, drive cell proliferation and prevent apoptosis, whereas KSHV lytic proteins, such as viral G protein-coupled receptor, K1 and virally encoded cytokines (viral interleukin-6 and viral chemokines) further contribute to the unique angioproliferative and inflammatory KS lesions through a mechanism called paracrine neoplasia.

Original language	English (US)
Pages (from-to)	707-719
Number of pages	13
Journal	Nature Reviews Cancer
Volume	10
Issue number	10
DOIs	https://doi.org/10.1038/nrc2888
State	Published - Oct 2010

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

10.1038/nrc2888

Fingerprint Dive into the research topics of 'Kaposi's sarcoma and its associated herpesvirus'. Together they form a unique fingerprint.

Cite this

@article{645560c22c4a4516b11b42601b84e02a,

title = "Kaposi's sarcoma and its associated herpesvirus",

abstract = "Kaposi's sarcoma (KS) is the most common cancer in HIV-infected untreated individuals. Kaposi's sarcoma-associated herpesvirus (KSHV; also known as human herpesvirus 8 (HHV8)) is the infectious cause of this neoplasm. In this Review we describe the epidemiology of KS and KSHV, and the insights into the remarkable mechanisms through which KSHV can induce KS that have been gained in the past 16 years. KSHV latent transcripts, such as latency-associated nuclear antigen (LANA), viral cyclin, viral FLIP and viral-encoded microRNAs, drive cell proliferation and prevent apoptosis, whereas KSHV lytic proteins, such as viral G protein-coupled receptor, K1 and virally encoded cytokines (viral interleukin-6 and viral chemokines) further contribute to the unique angioproliferative and inflammatory KS lesions through a mechanism called paracrine neoplasia.",

author = "Mesri, {Enrique A.} and Ethel Cesarman and Chris Boshoff",

note = "Funding Information: E.A.M. is supported by US National Institutes of Health grants CA75918 and CA136387, and C.B. by Cancer Research UK, the Medical Research Council and the University College London and University College London Hopsitals Comprehensive Biomedical Research Centre.",

year = "2010",

month = oct,

doi = "10.1038/nrc2888",

language = "English (US)",

volume = "10",

pages = "707--719",

journal = "Nature Reviews Cancer",

issn = "1474-175X",

publisher = "Nature Publishing Group",

number = "10",

}

TY - JOUR

T1 - Kaposi's sarcoma and its associated herpesvirus

AU - Mesri, Enrique A.

AU - Cesarman, Ethel

AU - Boshoff, Chris

N1 - Funding Information: E.A.M. is supported by US National Institutes of Health grants CA75918 and CA136387, and C.B. by Cancer Research UK, the Medical Research Council and the University College London and University College London Hopsitals Comprehensive Biomedical Research Centre.

PY - 2010/10

Y1 - 2010/10

N2 - Kaposi's sarcoma (KS) is the most common cancer in HIV-infected untreated individuals. Kaposi's sarcoma-associated herpesvirus (KSHV; also known as human herpesvirus 8 (HHV8)) is the infectious cause of this neoplasm. In this Review we describe the epidemiology of KS and KSHV, and the insights into the remarkable mechanisms through which KSHV can induce KS that have been gained in the past 16 years. KSHV latent transcripts, such as latency-associated nuclear antigen (LANA), viral cyclin, viral FLIP and viral-encoded microRNAs, drive cell proliferation and prevent apoptosis, whereas KSHV lytic proteins, such as viral G protein-coupled receptor, K1 and virally encoded cytokines (viral interleukin-6 and viral chemokines) further contribute to the unique angioproliferative and inflammatory KS lesions through a mechanism called paracrine neoplasia.

AB - Kaposi's sarcoma (KS) is the most common cancer in HIV-infected untreated individuals. Kaposi's sarcoma-associated herpesvirus (KSHV; also known as human herpesvirus 8 (HHV8)) is the infectious cause of this neoplasm. In this Review we describe the epidemiology of KS and KSHV, and the insights into the remarkable mechanisms through which KSHV can induce KS that have been gained in the past 16 years. KSHV latent transcripts, such as latency-associated nuclear antigen (LANA), viral cyclin, viral FLIP and viral-encoded microRNAs, drive cell proliferation and prevent apoptosis, whereas KSHV lytic proteins, such as viral G protein-coupled receptor, K1 and virally encoded cytokines (viral interleukin-6 and viral chemokines) further contribute to the unique angioproliferative and inflammatory KS lesions through a mechanism called paracrine neoplasia.

UR - http://www.scopus.com/inward/record.url?scp=77957121811&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77957121811&partnerID=8YFLogxK

U2 - 10.1038/nrc2888

DO - 10.1038/nrc2888

M3 - Review article

C2 - 20865011

AN - SCOPUS:77957121811

VL - 10

SP - 707

EP - 719

JO - Nature Reviews Cancer

JF - Nature Reviews Cancer

SN - 1474-175X

IS - 10

ER -