Kaposi's sarcoma: A new model in the search for viruses associated with human malignancies1, 2

G. Giraldo, E. Beth, P. Coeur, C. H. Vogel, D. S. Dhru

Research output: Contribution to journalArticle

68 Scopus citations

Abstract

Tumor, lymph node, and skin biopsies of Kaposi's sarcoma (KS) patients were obtained from different high incidence areas of equatorial Africa and France. A total of 51 lines were established in tissue culture:25 derived from tumor, 16 from lymph nodes, and 10 from skin biopsies.Long-term cultures had distinct, irregular growth patterns of cells, often noncontact-inhibited, with predominantly fibroblastoid or epithelioid characteristics. Cells were easily removed from the glass surface by trypsin and showed acid phosphatase and phagocytic activity to various degrees.Of 8 cultures (derived from cases of different regions) selected for study in greater detail, herpes-type viruses were observed in electron micrographs of 5. Comparative immunologic studies showed a common, precipitating, soluble antigen against human reference sera with high anti-cytomegalovirus (CMV) but low anti-Epstein-Barr virus (EBV) titers. In 4 cases, with high anti-EBV but low anti-CMV reactive sera from African Burkitt’s lymphoma patients, a common antigen was demonstrated. The possible implications of these results are discussed.

Original languageEnglish (US)
Pages (from-to)1495-1507
Number of pages13
JournalJournal of the National Cancer Institute
Volume49
Issue number6
DOIs
StatePublished - Dec 1972

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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