Abstract
The current study was performed to examine the mechanisms underlying the potential effects of E. kansui on IL-6-induced cellular signaling in human hepatoma cells. We found that two diterpenoids, kansuinine A and B, from E. kansui have an inhibitory effect on IL-6-induced Stat3 activation by activating ERK1/2. Inhibition of MEK significantly blocked the effects of kansuinine A and B on IL-6-induced Stat3 activation and tyrosine phosphorylation. These results suggest that blocking of IL-6-induced signal transduction is partially due to the sustained activation of ERK1/2 by kansuinine A and B, which in turn results in an increase of Stat3 serine phosphorylation and SOCS-3 expression. Treatment with kansuinine A and B represents a novel method to block these IL-6-induced effects.
Original language | English (US) |
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Pages (from-to) | 1544-1549 |
Number of pages | 6 |
Journal | Planta Medica |
Volume | 76 |
Issue number | 14 |
DOIs | |
State | Published - Oct 11 2010 |
Externally published | Yes |
Keywords
- ERK1/2
- Euphorbia kansui Liou
- Euphorbiaceae
- IL6
- kansuinine A
- kansuinine B
- Stat3
ASJC Scopus subject areas
- Complementary and alternative medicine
- Molecular Medicine
- Organic Chemistry
- Analytical Chemistry
- Pharmaceutical Science
- Pharmacology
- Drug Discovery