Kansuinine A and kansuinine B from Euphorbia kansui L. Inhibit IL-6-induced Stat3 activation

Jong Sun Chang, Seung Woong Lee, Mi Hye Park, Myo Sun Kim, Barry I. Hudson, Su Jin Park, Woo Song Lee, Mun Chual Rho

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

The current study was performed to examine the mechanisms underlying the potential effects of E. kansui on IL-6-induced cellular signaling in human hepatoma cells. We found that two diterpenoids, kansuinine A and B, from E. kansui have an inhibitory effect on IL-6-induced Stat3 activation by activating ERK1/2. Inhibition of MEK significantly blocked the effects of kansuinine A and B on IL-6-induced Stat3 activation and tyrosine phosphorylation. These results suggest that blocking of IL-6-induced signal transduction is partially due to the sustained activation of ERK1/2 by kansuinine A and B, which in turn results in an increase of Stat3 serine phosphorylation and SOCS-3 expression. Treatment with kansuinine A and B represents a novel method to block these IL-6-induced effects.

Original languageEnglish (US)
Pages (from-to)1544-1549
Number of pages6
JournalPlanta Medica
Volume76
Issue number14
DOIs
StatePublished - Oct 11 2010
Externally publishedYes

Keywords

  • ERK1/2
  • Euphorbia kansui Liou
  • Euphorbiaceae
  • IL6
  • kansuinine A
  • kansuinine B
  • Stat3

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Molecular Medicine
  • Organic Chemistry
  • Analytical Chemistry
  • Pharmaceutical Science
  • Pharmacology
  • Drug Discovery

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  • Cite this

    Chang, J. S., Lee, S. W., Park, M. H., Kim, M. S., Hudson, B. I., Park, S. J., Lee, W. S., & Rho, M. C. (2010). Kansuinine A and kansuinine B from Euphorbia kansui L. Inhibit IL-6-induced Stat3 activation. Planta Medica, 76(14), 1544-1549. https://doi.org/10.1055/s-0030-1249805