Kansuinine A and kansuinine B from Euphorbia kansui L. Inhibit IL-6-induced Stat3 activation

Jong Sun Chang; Seung Woong Lee; Mi Hye Park; Myo Sun Kim; Barry I. Hudson; Su Jin Park; Woo Song Lee; Mun Chual Rho

doi:10.1055/s-0030-1249805

Kansuinine A and kansuinine B from Euphorbia kansui L. Inhibit IL-6-induced Stat3 activation

Jong Sun Chang, Seung Woong Lee, Mi Hye Park, Myo Sun Kim, Barry I. Hudson, Su Jin Park, Woo Song Lee, Mun Chual Rho

Research output: Contribution to journal › Article

13 Scopus citations

Abstract

The current study was performed to examine the mechanisms underlying the potential effects of E. kansui on IL-6-induced cellular signaling in human hepatoma cells. We found that two diterpenoids, kansuinine A and B, from E. kansui have an inhibitory effect on IL-6-induced Stat3 activation by activating ERK1/2. Inhibition of MEK significantly blocked the effects of kansuinine A and B on IL-6-induced Stat3 activation and tyrosine phosphorylation. These results suggest that blocking of IL-6-induced signal transduction is partially due to the sustained activation of ERK1/2 by kansuinine A and B, which in turn results in an increase of Stat3 serine phosphorylation and SOCS-3 expression. Treatment with kansuinine A and B represents a novel method to block these IL-6-induced effects.

Original language	English (US)
Pages (from-to)	1544-1549
Number of pages	6
Journal	Planta Medica
Volume	76
Issue number	14
DOIs	https://doi.org/10.1055/s-0030-1249805
State	Published - Oct 11 2010
Externally published	Yes

Keywords

ERK1/2
Euphorbia kansui Liou
Euphorbiaceae
IL6
kansuinine A
kansuinine B
Stat3

ASJC Scopus subject areas

Complementary and alternative medicine
Molecular Medicine
Organic Chemistry
Analytical Chemistry
Pharmaceutical Science
Pharmacology
Drug Discovery

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Chang, J. S., Lee, S. W., Park, M. H., Kim, M. S., Hudson, B. I., Park, S. J., Lee, W. S., & Rho, M. C. (2010). Kansuinine A and kansuinine B from Euphorbia kansui L. Inhibit IL-6-induced Stat3 activation. Planta Medica, 76(14), 1544-1549. https://doi.org/10.1055/s-0030-1249805

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abstract = "The current study was performed to examine the mechanisms underlying the potential effects of E. kansui on IL-6-induced cellular signaling in human hepatoma cells. We found that two diterpenoids, kansuinine A and B, from E. kansui have an inhibitory effect on IL-6-induced Stat3 activation by activating ERK1/2. Inhibition of MEK significantly blocked the effects of kansuinine A and B on IL-6-induced Stat3 activation and tyrosine phosphorylation. These results suggest that blocking of IL-6-induced signal transduction is partially due to the sustained activation of ERK1/2 by kansuinine A and B, which in turn results in an increase of Stat3 serine phosphorylation and SOCS-3 expression. Treatment with kansuinine A and B represents a novel method to block these IL-6-induced effects.",

keywords = "ERK1/2, Euphorbia kansui Liou, Euphorbiaceae, IL6, kansuinine A, kansuinine B, Stat3",

author = "Chang, {Jong Sun} and Lee, {Seung Woong} and Park, {Mi Hye} and Kim, {Myo Sun} and Hudson, {Barry I.} and Park, {Su Jin} and Lee, {Woo Song} and Rho, {Mun Chual}",

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AU - Chang, Jong Sun

AU - Lee, Seung Woong

AU - Park, Mi Hye

AU - Kim, Myo Sun

AU - Hudson, Barry I.

AU - Park, Su Jin

AU - Lee, Woo Song

AU - Rho, Mun Chual

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N2 - The current study was performed to examine the mechanisms underlying the potential effects of E. kansui on IL-6-induced cellular signaling in human hepatoma cells. We found that two diterpenoids, kansuinine A and B, from E. kansui have an inhibitory effect on IL-6-induced Stat3 activation by activating ERK1/2. Inhibition of MEK significantly blocked the effects of kansuinine A and B on IL-6-induced Stat3 activation and tyrosine phosphorylation. These results suggest that blocking of IL-6-induced signal transduction is partially due to the sustained activation of ERK1/2 by kansuinine A and B, which in turn results in an increase of Stat3 serine phosphorylation and SOCS-3 expression. Treatment with kansuinine A and B represents a novel method to block these IL-6-induced effects.

AB - The current study was performed to examine the mechanisms underlying the potential effects of E. kansui on IL-6-induced cellular signaling in human hepatoma cells. We found that two diterpenoids, kansuinine A and B, from E. kansui have an inhibitory effect on IL-6-induced Stat3 activation by activating ERK1/2. Inhibition of MEK significantly blocked the effects of kansuinine A and B on IL-6-induced Stat3 activation and tyrosine phosphorylation. These results suggest that blocking of IL-6-induced signal transduction is partially due to the sustained activation of ERK1/2 by kansuinine A and B, which in turn results in an increase of Stat3 serine phosphorylation and SOCS-3 expression. Treatment with kansuinine A and B represents a novel method to block these IL-6-induced effects.

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KW - kansuinine B

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