Abstract
The current study was performed to examine the mechanisms underlying the potential effects of E. kansui on IL-6-induced cellular signaling in human hepatoma cells. We found that two diterpenoids, kansuinine A and B, from E. kansui have an inhibitory effect on IL-6-induced Stat3 activation by activating ERK1/2. Inhibition of MEK significantly blocked the effects of kansuinine A and B on IL-6-induced Stat3 activation and tyrosine phosphorylation. These results suggest that blocking of IL-6-induced signal transduction is partially due to the sustained activation of ERK1/2 by kansuinine A and B, which in turn results in an increase of Stat3 serine phosphorylation and SOCS-3 expression. Treatment with kansuinine A and B represents a novel method to block these IL-6-induced effects.
| Original language | English |
|---|---|
| Pages (from-to) | 1544-1549 |
| Number of pages | 6 |
| Journal | Planta Medica |
| Volume | 76 |
| Issue number | 14 |
| DOIs | |
| State | Published - Oct 11 2010 |
| Externally published | Yes |
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Keywords
- ERK1/2
- Euphorbia kansui Liou
- Euphorbiaceae
- IL6
- kansuinine A
- kansuinine B
- Stat3
ASJC Scopus subject areas
- Complementary and alternative medicine
- Molecular Medicine
- Organic Chemistry
- Analytical Chemistry
- Pharmaceutical Science
- Pharmacology
- Drug Discovery
Cite this
Kansuinine A and kansuinine B from Euphorbia kansui L. Inhibit IL-6-induced Stat3 activation. / Chang, Jong Sun; Lee, Seung Woong; Park, Mi Hye; Kim, Myo Sun; Hudson, Barry; Park, Su Jin; Lee, Woo Song; Rho, Mun Chual.
In: Planta Medica, Vol. 76, No. 14, 11.10.2010, p. 1544-1549.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Kansuinine A and kansuinine B from Euphorbia kansui L. Inhibit IL-6-induced Stat3 activation
AU - Chang, Jong Sun
AU - Lee, Seung Woong
AU - Park, Mi Hye
AU - Kim, Myo Sun
AU - Hudson, Barry
AU - Park, Su Jin
AU - Lee, Woo Song
AU - Rho, Mun Chual
PY - 2010/10/11
Y1 - 2010/10/11
N2 - The current study was performed to examine the mechanisms underlying the potential effects of E. kansui on IL-6-induced cellular signaling in human hepatoma cells. We found that two diterpenoids, kansuinine A and B, from E. kansui have an inhibitory effect on IL-6-induced Stat3 activation by activating ERK1/2. Inhibition of MEK significantly blocked the effects of kansuinine A and B on IL-6-induced Stat3 activation and tyrosine phosphorylation. These results suggest that blocking of IL-6-induced signal transduction is partially due to the sustained activation of ERK1/2 by kansuinine A and B, which in turn results in an increase of Stat3 serine phosphorylation and SOCS-3 expression. Treatment with kansuinine A and B represents a novel method to block these IL-6-induced effects.
AB - The current study was performed to examine the mechanisms underlying the potential effects of E. kansui on IL-6-induced cellular signaling in human hepatoma cells. We found that two diterpenoids, kansuinine A and B, from E. kansui have an inhibitory effect on IL-6-induced Stat3 activation by activating ERK1/2. Inhibition of MEK significantly blocked the effects of kansuinine A and B on IL-6-induced Stat3 activation and tyrosine phosphorylation. These results suggest that blocking of IL-6-induced signal transduction is partially due to the sustained activation of ERK1/2 by kansuinine A and B, which in turn results in an increase of Stat3 serine phosphorylation and SOCS-3 expression. Treatment with kansuinine A and B represents a novel method to block these IL-6-induced effects.
KW - ERK1/2
KW - Euphorbia kansui Liou
KW - Euphorbiaceae
KW - IL6
KW - kansuinine A
KW - kansuinine B
KW - Stat3
UR - http://www.scopus.com/inward/record.url?scp=77957564264&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77957564264&partnerID=8YFLogxK
U2 - 10.1055/s-0030-1249805
DO - 10.1055/s-0030-1249805
M3 - Article
C2 - 20379953
AN - SCOPUS:77957564264
VL - 76
SP - 1544
EP - 1549
JO - Planta Medica
JF - Planta Medica
SN - 0032-0943
IS - 14
ER -