Juvenile cystic kidneys (jck)

A new mouse mutation which causes polycystic kidneys

Anthony Atala, Michael R. Freeman, James Mandell, David R. Beier

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

We have characterized a new recessive mutation in the mouse which predisposes to the development of polycystic kidney disease. This mutation, called juvenile cystic kidneys (jck), arose in a transgenic line of mice, but appears unrelated to the transgene since it segregates freely from it. While focal cysts are evident in affected animals as early as three days of life and the disease is progressive, the mice are fertile and generally survive to four or more months of age. Complementation analysis indicates that the jck mutation is not allelic with three other known recessive polycystic kidney mutations (cpk and two as yet unnamed mutations), and linkage studies demonstrate it is unlikely to be allelic with a fourth (pcy). The study of these five mutations and their interactions should prove useful for understanding the mechanisms required to maintain the normal integrity of renal tubules.

Original languageEnglish
Pages (from-to)1081-1085
Number of pages5
JournalKidney International
Volume43
Issue number5
StatePublished - May 1 1993
Externally publishedYes

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Cystic Kidney Diseases
Polycystic Kidney Diseases
Mutation
Transgenes
Transgenic Mice
Cysts
Kidney

ASJC Scopus subject areas

  • Nephrology

Cite this

Atala, A., Freeman, M. R., Mandell, J., & Beier, D. R. (1993). Juvenile cystic kidneys (jck): A new mouse mutation which causes polycystic kidneys. Kidney International, 43(5), 1081-1085.

Juvenile cystic kidneys (jck) : A new mouse mutation which causes polycystic kidneys. / Atala, Anthony; Freeman, Michael R.; Mandell, James; Beier, David R.

In: Kidney International, Vol. 43, No. 5, 01.05.1993, p. 1081-1085.

Research output: Contribution to journalArticle

Atala, A, Freeman, MR, Mandell, J & Beier, DR 1993, 'Juvenile cystic kidneys (jck): A new mouse mutation which causes polycystic kidneys', Kidney International, vol. 43, no. 5, pp. 1081-1085.
Atala A, Freeman MR, Mandell J, Beier DR. Juvenile cystic kidneys (jck): A new mouse mutation which causes polycystic kidneys. Kidney International. 1993 May 1;43(5):1081-1085.
Atala, Anthony ; Freeman, Michael R. ; Mandell, James ; Beier, David R. / Juvenile cystic kidneys (jck) : A new mouse mutation which causes polycystic kidneys. In: Kidney International. 1993 ; Vol. 43, No. 5. pp. 1081-1085.
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