Abstract
BACKGROUND: Preinfarction angina (PrA), clinical equivalent of ischemic preconditioning, confers protection against in-hospital mortality for acute myocardial infarction (AMI) in adult but not in elderly patients. This study aims to examine the interaction between physical activity and body mass index (BMI) in preserving the cardioprotective effect of PrA in elderly patients with AMI. DESIGN: Elderly patients (≥65 years old) with AMI admitted to Coronary Care Unit. METHODS: Elderly patients with AMI were retrospectively stratified for the presence and absence of PrA, and for quartiles of BMI and physical activity. In-hospital outcomes (death, cardiogenic shock, and reinfarction and creatine kinase-MB peak) were evaluated. RESULTS: In-hospital mortality of 1014 elderly patients with AMI was 19.2% in those with PrA and 22.7% in those without (P=0.18, NS). Mortality further decreased with increased physical activity and reduced BMI, a trend that was not observed in patients without PrA. When physical activity and BMI were considered together, lowest in-hospital mortality was observed in patients with highest physical activity and normal BMI (from 18.2 to 9.6%; P<0.01) with the greatest reduction observed in patients with PrA (from 18.3 to 5.1%; P=0.02). Multivariate analysis showed that PrA did not exert a protective effect in all patients irrespective of physical activity and BMI. A protective role was, however, observed in patients with highest physical activity or normal BMI and reached a maximum protective role in patients who showed both highest physical activity and normal BMI [odds ratio=0.08; 95% confidence interval=0.02-0.72; P<0.01]. CONCLUSION: The cardioprotective effect of PrA was preserved in elderly patients who showed the highest physical activity and a normal BMI.
| Original language | English |
|---|---|
| Pages (from-to) | 73-79 |
| Number of pages | 7 |
| Journal | European Journal of Cardiovascular Prevention and Rehabilitation |
| Volume | 16 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 1 2009 |
| Externally published | Yes |
Fingerprint
Keywords
- Elderly
- Lifestyles
- Mortality
- Myocardial infarction
- Preinfarction angina
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Epidemiology
- Medicine(all)
Cite this
Joint effect of physical activity and body mass index on mortality for acute myocardial infarction in the elderly : Role of preinfarction angina as equivalent of ischemic preconditioning. / Abete, Pasquale; Cacciatore, Francesco; Della Morte, David; Mazzella, Francesca; Testa, Gianluca; Galizia, Gianluigi; De Santis, Domenico; Longobardi, Giancarlo; Ferrara, Nicola; Rengo, Franco.
In: European Journal of Cardiovascular Prevention and Rehabilitation, Vol. 16, No. 1, 01.02.2009, p. 73-79.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Joint effect of physical activity and body mass index on mortality for acute myocardial infarction in the elderly
T2 - Role of preinfarction angina as equivalent of ischemic preconditioning
AU - Abete, Pasquale
AU - Cacciatore, Francesco
AU - Della Morte, David
AU - Mazzella, Francesca
AU - Testa, Gianluca
AU - Galizia, Gianluigi
AU - De Santis, Domenico
AU - Longobardi, Giancarlo
AU - Ferrara, Nicola
AU - Rengo, Franco
PY - 2009/2/1
Y1 - 2009/2/1
N2 - BACKGROUND: Preinfarction angina (PrA), clinical equivalent of ischemic preconditioning, confers protection against in-hospital mortality for acute myocardial infarction (AMI) in adult but not in elderly patients. This study aims to examine the interaction between physical activity and body mass index (BMI) in preserving the cardioprotective effect of PrA in elderly patients with AMI. DESIGN: Elderly patients (≥65 years old) with AMI admitted to Coronary Care Unit. METHODS: Elderly patients with AMI were retrospectively stratified for the presence and absence of PrA, and for quartiles of BMI and physical activity. In-hospital outcomes (death, cardiogenic shock, and reinfarction and creatine kinase-MB peak) were evaluated. RESULTS: In-hospital mortality of 1014 elderly patients with AMI was 19.2% in those with PrA and 22.7% in those without (P=0.18, NS). Mortality further decreased with increased physical activity and reduced BMI, a trend that was not observed in patients without PrA. When physical activity and BMI were considered together, lowest in-hospital mortality was observed in patients with highest physical activity and normal BMI (from 18.2 to 9.6%; P<0.01) with the greatest reduction observed in patients with PrA (from 18.3 to 5.1%; P=0.02). Multivariate analysis showed that PrA did not exert a protective effect in all patients irrespective of physical activity and BMI. A protective role was, however, observed in patients with highest physical activity or normal BMI and reached a maximum protective role in patients who showed both highest physical activity and normal BMI [odds ratio=0.08; 95% confidence interval=0.02-0.72; P<0.01]. CONCLUSION: The cardioprotective effect of PrA was preserved in elderly patients who showed the highest physical activity and a normal BMI.
AB - BACKGROUND: Preinfarction angina (PrA), clinical equivalent of ischemic preconditioning, confers protection against in-hospital mortality for acute myocardial infarction (AMI) in adult but not in elderly patients. This study aims to examine the interaction between physical activity and body mass index (BMI) in preserving the cardioprotective effect of PrA in elderly patients with AMI. DESIGN: Elderly patients (≥65 years old) with AMI admitted to Coronary Care Unit. METHODS: Elderly patients with AMI were retrospectively stratified for the presence and absence of PrA, and for quartiles of BMI and physical activity. In-hospital outcomes (death, cardiogenic shock, and reinfarction and creatine kinase-MB peak) were evaluated. RESULTS: In-hospital mortality of 1014 elderly patients with AMI was 19.2% in those with PrA and 22.7% in those without (P=0.18, NS). Mortality further decreased with increased physical activity and reduced BMI, a trend that was not observed in patients without PrA. When physical activity and BMI were considered together, lowest in-hospital mortality was observed in patients with highest physical activity and normal BMI (from 18.2 to 9.6%; P<0.01) with the greatest reduction observed in patients with PrA (from 18.3 to 5.1%; P=0.02). Multivariate analysis showed that PrA did not exert a protective effect in all patients irrespective of physical activity and BMI. A protective role was, however, observed in patients with highest physical activity or normal BMI and reached a maximum protective role in patients who showed both highest physical activity and normal BMI [odds ratio=0.08; 95% confidence interval=0.02-0.72; P<0.01]. CONCLUSION: The cardioprotective effect of PrA was preserved in elderly patients who showed the highest physical activity and a normal BMI.
KW - Elderly
KW - Lifestyles
KW - Mortality
KW - Myocardial infarction
KW - Preinfarction angina
UR - http://www.scopus.com/inward/record.url?scp=65649130437&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=65649130437&partnerID=8YFLogxK
U2 - 10.1097/HJR.0b013e32831e9525
DO - 10.1097/HJR.0b013e32831e9525
M3 - Article
C2 - 19188807
AN - SCOPUS:65649130437
VL - 16
SP - 73
EP - 79
JO - European Journal of Preventive Cardiology
JF - European Journal of Preventive Cardiology
SN - 2047-4873
IS - 1
ER -