Jekyll and Hyde: Activating the Hypoxic Translational Machinery

J. J.David Ho, Jonathan H. Schatz, Jim Uniacke, Stephen Lee

Research output: Contribution to journalShort surveypeer-review

Abstract

Global translational remodeling has emerged as a principal mechanism of biological adaptation. Oxygen deficiency (hypoxia) disables the basal protein synthesis machinery (‘Jekyll’) and activates a hypoxic translational architecture (‘Hyde’) to drive translatome remodeling. Independent from mRNA-level fluctuations, this newer paradigm modernizes a field traditionally dominated by the hypoxia-inducible factor (HIF) transcriptional program.

Original languageEnglish (US)
JournalTrends in Biochemical Sciences
DOIs
StateAccepted/In press - 2020

Keywords

  • HIF
  • hypoxia
  • oxygen
  • protein synthesis
  • translation heterogeneity
  • translatome

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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