Jarid2 regulates mouse epidermal stem cell activation and differentiation

Stefania Mejetta, Lluis Morey, Gloria Pascual, Bernd Kuebler, Matthew R. Mysliwiec, Youngsook Lee, Ramin Shiekhattar, Luciano Di Croce, Salvador Aznar Benitah

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


Jarid2 is required for the genomic recruitment of the polycomb repressive complex-2 (PRC2) in embryonic stem cells. However, its specific role during late development and adult tissues remains largely uncharacterized. Here, we show that deletion of Jarid2 in mouse epidermis reduces the proliferation and potentiates the differentiation of postnatal epidermal progenitors, without affecting epidermal development. In neonatal epidermis, Jarid2 deficiency reduces H3K27 trimethylation, a chromatin repressive mark, in epidermal differentiation genes previously shown to be targets of the PRC2. However, in adult epidermis Jarid2 depletion does not affect interfollicular epidermal differentiation but results in delayed hair follicle (HF) cycling as a consequence of decreased proliferation of HF stem cells and their progeny. We conclude that Jarid2 is required for the scheduled proliferation of epidermal stem and progenitor cells necessary to maintain epidermal homeostasis.

Original languageEnglish (US)
Pages (from-to)3635-3646
Number of pages12
JournalEMBO Journal
Issue number17
StatePublished - Aug 31 2011
Externally publishedYes


  • Jarid2
  • epidermal homeostasis
  • epidermal stem cells
  • polycomb group proteins
  • polycomb repressive complex-2

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)


Dive into the research topics of 'Jarid2 regulates mouse epidermal stem cell activation and differentiation'. Together they form a unique fingerprint.

Cite this