Jarid2 regulates mouse epidermal stem cell activation and differentiation

Stefania Mejetta, LLuis Morey, Gloria Pascual, Bernd Kuebler, Matthew R. Mysliwiec, Youngsook Lee, Ramin Shiekhattar, Luciano Di Croce, Salvador Aznar Benitah

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Jarid2 is required for the genomic recruitment of the polycomb repressive complex-2 (PRC2) in embryonic stem cells. However, its specific role during late development and adult tissues remains largely uncharacterized. Here, we show that deletion of Jarid2 in mouse epidermis reduces the proliferation and potentiates the differentiation of postnatal epidermal progenitors, without affecting epidermal development. In neonatal epidermis, Jarid2 deficiency reduces H3K27 trimethylation, a chromatin repressive mark, in epidermal differentiation genes previously shown to be targets of the PRC2. However, in adult epidermis Jarid2 depletion does not affect interfollicular epidermal differentiation but results in delayed hair follicle (HF) cycling as a consequence of decreased proliferation of HF stem cells and their progeny. We conclude that Jarid2 is required for the scheduled proliferation of epidermal stem and progenitor cells necessary to maintain epidermal homeostasis.

Original languageEnglish (US)
Pages (from-to)3635-3646
Number of pages12
JournalEMBO Journal
Volume30
Issue number17
DOIs
StatePublished - Aug 31 2011
Externally publishedYes

Fingerprint

Polycomb Repressive Complex 2
Stem cells
Epidermis
Cell Differentiation
Stem Cells
Hair Follicle
Chemical activation
Chromatin
Genes
Tissue
Embryonic Stem Cells
Homeostasis

Keywords

  • epidermal homeostasis
  • epidermal stem cells
  • Jarid2
  • polycomb group proteins
  • polycomb repressive complex-2

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Neuroscience(all)

Cite this

Mejetta, S., Morey, LL., Pascual, G., Kuebler, B., Mysliwiec, M. R., Lee, Y., ... Benitah, S. A. (2011). Jarid2 regulates mouse epidermal stem cell activation and differentiation. EMBO Journal, 30(17), 3635-3646. https://doi.org/10.1038/emboj.2011.265

Jarid2 regulates mouse epidermal stem cell activation and differentiation. / Mejetta, Stefania; Morey, LLuis; Pascual, Gloria; Kuebler, Bernd; Mysliwiec, Matthew R.; Lee, Youngsook; Shiekhattar, Ramin; Di Croce, Luciano; Benitah, Salvador Aznar.

In: EMBO Journal, Vol. 30, No. 17, 31.08.2011, p. 3635-3646.

Research output: Contribution to journalArticle

Mejetta, S, Morey, LL, Pascual, G, Kuebler, B, Mysliwiec, MR, Lee, Y, Shiekhattar, R, Di Croce, L & Benitah, SA 2011, 'Jarid2 regulates mouse epidermal stem cell activation and differentiation', EMBO Journal, vol. 30, no. 17, pp. 3635-3646. https://doi.org/10.1038/emboj.2011.265
Mejetta S, Morey LL, Pascual G, Kuebler B, Mysliwiec MR, Lee Y et al. Jarid2 regulates mouse epidermal stem cell activation and differentiation. EMBO Journal. 2011 Aug 31;30(17):3635-3646. https://doi.org/10.1038/emboj.2011.265
Mejetta, Stefania ; Morey, LLuis ; Pascual, Gloria ; Kuebler, Bernd ; Mysliwiec, Matthew R. ; Lee, Youngsook ; Shiekhattar, Ramin ; Di Croce, Luciano ; Benitah, Salvador Aznar. / Jarid2 regulates mouse epidermal stem cell activation and differentiation. In: EMBO Journal. 2011 ; Vol. 30, No. 17. pp. 3635-3646.
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