I.V. Temazepam: Theoretical and clinical considerations

N. J. Halliday, J. W. Dundee, R. J.T. Carlisle, E. Mcclean

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Two injectable forms of temazepam, in 90% propylene glycol or 40% salicylic acid, were studied in volunteers, and before surgery in healthy patients. The volunteers also received two forms (capsule and elixir) by mouth. The salicylate preparation was painful on injection and both i.v. formulations caused an unacceptably high incidence of venous thrombosis. Temazepam was detected in plasma earlier following the elixir preparation than the capsule. Plasma concentrations were similar following both injectable preparations. The potency of i.v. temazepam in inducing drowsiness in patients was much less than expected and doses greater than 0.6 mg kg-1 were required to produce adequate sedation. There was a significant reduction in thiopentone induction dose in patients receiving temazepam i.v.

Original languageEnglish (US)
Pages (from-to)465-467
Number of pages3
JournalBritish Journal of Anaesthesia
Volume59
Issue number4
DOIs
StatePublished - Apr 1987

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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    Halliday, N. J., Dundee, J. W., Carlisle, R. J. T., & Mcclean, E. (1987). I.V. Temazepam: Theoretical and clinical considerations. British Journal of Anaesthesia, 59(4), 465-467. https://doi.org/10.1093/bja/59.4.465