Itchy body: Topographical difference of itch and scratching and C Nerve fibres

Takashi Hashimoto, Gil Yosipovitch

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Itch, also known as pruritus, is an unpleasant sensation that results in an urge to scratch. We can feel itch at any location where itch occurs from the top of the head to the toes. However, there are topographical differences in itch intensity. Itch is mainly conducted by C nerve fibres from the skin where itch emanates to the central nervous system. However, the abundancy of C fibres does not necessarily lead to higher itch intensity. Interestingly, reduction and/or structural changes in C fibres seem to play a role in itch sensation. In addition, C tactile fibres (CT afferents), which are activated by gentle “affective” touch and seem to be associated with scratching pleasurability and the reward system in the brain, can be involved in itch sensation and topographical differences of itch.

Original languageEnglish (US)
Pages (from-to)1385-1389
Number of pages5
JournalExperimental dermatology
Issue number12
StatePublished - Dec 1 2019


  • C tactile afferents
  • itch
  • pruritus
  • reward system
  • scratching plearsurability

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology


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