Itching-related somatosensory evoked potentials

Hideki Mochizuki, Kouji Inui, Koya Yamashiro, Naohumi Ootsuru, Ryusuke Kakigi

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Electrically evoked itching has the strong potential to be used to investigate the central processing associated with itching at high temporal resolution by employing magnetoencephalography, electroencephalography (EEG), and event-related functional magnetic resonance imaging. However, it has not been investigated whether time-locked brain activity can be measured using this stimulus, and whether the itching sensation induced by electrical stimulation of the skin is associated with C-fibers. Thus, we investigated these problems in this study. Itching sensations were elicited when electrical stimuli were applied to the skin of the right wrist and right forearm. EEG activity was recorded from 5 electrodes (Fz, FCz, Cz, CPz and Pz). When the right wrist was stimulated, the reaction time (RT) and latency of the positive component of somatosensory evoked potentials (P1) were 1215 ms and 963 ms, respectively. When the right forearm was stimulated, the RT and peak latency of the P1 were 1013 ms and 772 ms, respectively. The conduction velocity estimated from the RT and latency of the P1 was 1.04 m/s and 0.92 m/s, respectively. In addition, the itching sensation and P1 were inhibited when the current intensity was increased into the range eliciting pain and touch sensations, implying interaction between C- and A-fibers. These findings demonstrate that time-locked brain activity can be measured using electrically evoked itching and that the itching sensation induced by the electrically evoked itching is associated with C-fibers. Thus, this method is useful for research into the central processing of itching.

Original languageEnglish (US)
Pages (from-to)598-603
Number of pages6
JournalPain
Volume138
Issue number3
DOIs
StatePublished - Sep 15 2008
Externally publishedYes

Fingerprint

Somatosensory Evoked Potentials
Pruritus
Reaction Time
Unmyelinated Nerve Fibers
Wrist
Forearm
Electroencephalography
Magnetoencephalography
Myelinated Nerve Fibers
Skin
Brain
Touch
Electric Stimulation
Electrodes
Magnetic Resonance Imaging
Pain

Keywords

  • C-fibers
  • Electrically evoked itching
  • Somatosensory evoked potential

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Neurology
  • Neuroscience(all)
  • Pharmacology
  • Clinical Psychology

Cite this

Mochizuki, H., Inui, K., Yamashiro, K., Ootsuru, N., & Kakigi, R. (2008). Itching-related somatosensory evoked potentials. Pain, 138(3), 598-603. https://doi.org/10.1016/j.pain.2008.02.017

Itching-related somatosensory evoked potentials. / Mochizuki, Hideki; Inui, Kouji; Yamashiro, Koya; Ootsuru, Naohumi; Kakigi, Ryusuke.

In: Pain, Vol. 138, No. 3, 15.09.2008, p. 598-603.

Research output: Contribution to journalArticle

Mochizuki, H, Inui, K, Yamashiro, K, Ootsuru, N & Kakigi, R 2008, 'Itching-related somatosensory evoked potentials', Pain, vol. 138, no. 3, pp. 598-603. https://doi.org/10.1016/j.pain.2008.02.017
Mochizuki H, Inui K, Yamashiro K, Ootsuru N, Kakigi R. Itching-related somatosensory evoked potentials. Pain. 2008 Sep 15;138(3):598-603. https://doi.org/10.1016/j.pain.2008.02.017
Mochizuki, Hideki ; Inui, Kouji ; Yamashiro, Koya ; Ootsuru, Naohumi ; Kakigi, Ryusuke. / Itching-related somatosensory evoked potentials. In: Pain. 2008 ; Vol. 138, No. 3. pp. 598-603.
@article{42a327339e114a148327cbcbfc2d238b,
title = "Itching-related somatosensory evoked potentials",
abstract = "Electrically evoked itching has the strong potential to be used to investigate the central processing associated with itching at high temporal resolution by employing magnetoencephalography, electroencephalography (EEG), and event-related functional magnetic resonance imaging. However, it has not been investigated whether time-locked brain activity can be measured using this stimulus, and whether the itching sensation induced by electrical stimulation of the skin is associated with C-fibers. Thus, we investigated these problems in this study. Itching sensations were elicited when electrical stimuli were applied to the skin of the right wrist and right forearm. EEG activity was recorded from 5 electrodes (Fz, FCz, Cz, CPz and Pz). When the right wrist was stimulated, the reaction time (RT) and latency of the positive component of somatosensory evoked potentials (P1) were 1215 ms and 963 ms, respectively. When the right forearm was stimulated, the RT and peak latency of the P1 were 1013 ms and 772 ms, respectively. The conduction velocity estimated from the RT and latency of the P1 was 1.04 m/s and 0.92 m/s, respectively. In addition, the itching sensation and P1 were inhibited when the current intensity was increased into the range eliciting pain and touch sensations, implying interaction between C- and A-fibers. These findings demonstrate that time-locked brain activity can be measured using electrically evoked itching and that the itching sensation induced by the electrically evoked itching is associated with C-fibers. Thus, this method is useful for research into the central processing of itching.",
keywords = "C-fibers, Electrically evoked itching, Somatosensory evoked potential",
author = "Hideki Mochizuki and Kouji Inui and Koya Yamashiro and Naohumi Ootsuru and Ryusuke Kakigi",
year = "2008",
month = "9",
day = "15",
doi = "10.1016/j.pain.2008.02.017",
language = "English (US)",
volume = "138",
pages = "598--603",
journal = "Pain",
issn = "0304-3959",
publisher = "Elsevier",
number = "3",

}

TY - JOUR

T1 - Itching-related somatosensory evoked potentials

AU - Mochizuki, Hideki

AU - Inui, Kouji

AU - Yamashiro, Koya

AU - Ootsuru, Naohumi

AU - Kakigi, Ryusuke

PY - 2008/9/15

Y1 - 2008/9/15

N2 - Electrically evoked itching has the strong potential to be used to investigate the central processing associated with itching at high temporal resolution by employing magnetoencephalography, electroencephalography (EEG), and event-related functional magnetic resonance imaging. However, it has not been investigated whether time-locked brain activity can be measured using this stimulus, and whether the itching sensation induced by electrical stimulation of the skin is associated with C-fibers. Thus, we investigated these problems in this study. Itching sensations were elicited when electrical stimuli were applied to the skin of the right wrist and right forearm. EEG activity was recorded from 5 electrodes (Fz, FCz, Cz, CPz and Pz). When the right wrist was stimulated, the reaction time (RT) and latency of the positive component of somatosensory evoked potentials (P1) were 1215 ms and 963 ms, respectively. When the right forearm was stimulated, the RT and peak latency of the P1 were 1013 ms and 772 ms, respectively. The conduction velocity estimated from the RT and latency of the P1 was 1.04 m/s and 0.92 m/s, respectively. In addition, the itching sensation and P1 were inhibited when the current intensity was increased into the range eliciting pain and touch sensations, implying interaction between C- and A-fibers. These findings demonstrate that time-locked brain activity can be measured using electrically evoked itching and that the itching sensation induced by the electrically evoked itching is associated with C-fibers. Thus, this method is useful for research into the central processing of itching.

AB - Electrically evoked itching has the strong potential to be used to investigate the central processing associated with itching at high temporal resolution by employing magnetoencephalography, electroencephalography (EEG), and event-related functional magnetic resonance imaging. However, it has not been investigated whether time-locked brain activity can be measured using this stimulus, and whether the itching sensation induced by electrical stimulation of the skin is associated with C-fibers. Thus, we investigated these problems in this study. Itching sensations were elicited when electrical stimuli were applied to the skin of the right wrist and right forearm. EEG activity was recorded from 5 electrodes (Fz, FCz, Cz, CPz and Pz). When the right wrist was stimulated, the reaction time (RT) and latency of the positive component of somatosensory evoked potentials (P1) were 1215 ms and 963 ms, respectively. When the right forearm was stimulated, the RT and peak latency of the P1 were 1013 ms and 772 ms, respectively. The conduction velocity estimated from the RT and latency of the P1 was 1.04 m/s and 0.92 m/s, respectively. In addition, the itching sensation and P1 were inhibited when the current intensity was increased into the range eliciting pain and touch sensations, implying interaction between C- and A-fibers. These findings demonstrate that time-locked brain activity can be measured using electrically evoked itching and that the itching sensation induced by the electrically evoked itching is associated with C-fibers. Thus, this method is useful for research into the central processing of itching.

KW - C-fibers

KW - Electrically evoked itching

KW - Somatosensory evoked potential

UR - http://www.scopus.com/inward/record.url?scp=50249164241&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=50249164241&partnerID=8YFLogxK

U2 - 10.1016/j.pain.2008.02.017

DO - 10.1016/j.pain.2008.02.017

M3 - Article

VL - 138

SP - 598

EP - 603

JO - Pain

JF - Pain

SN - 0304-3959

IS - 3

ER -