Abstract
Pruritus is a sensation that emanates from the skin and is transferred through peripheral nerve fibers to the central nervous system. It is easily understood that primary skin disorders, such as atopic eczema, skin dryness, psoriasis, and urticaria, can elicit pruritus. However, certain systemic diseases can cause chronic pruritus, which has a significant effect on the patient's quality of life. In this rostrum we provide an overview of the characteristics, pathophysiology, and mechanisms of pruritus of major systemic underlying diseases, including end-stage renal disease, cholestatic liver disease, endocrine/metabolic diseases, and hematologic/lymphoproliferative diseases.
| Original language | English (US) |
|---|---|
| Journal | Journal of Allergy and Clinical Immunology |
| DOIs | |
| State | Published - Jan 1 2019 |
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Keywords
- Itch
- pruritus
- systemic disease
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
Cite this
Itching as a systemic disease. / Hashimoto, Takashi; Yosipovitch, Gil.
In: Journal of Allergy and Clinical Immunology, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Itching as a systemic disease
AU - Hashimoto, Takashi
AU - Yosipovitch, Gil
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Pruritus is a sensation that emanates from the skin and is transferred through peripheral nerve fibers to the central nervous system. It is easily understood that primary skin disorders, such as atopic eczema, skin dryness, psoriasis, and urticaria, can elicit pruritus. However, certain systemic diseases can cause chronic pruritus, which has a significant effect on the patient's quality of life. In this rostrum we provide an overview of the characteristics, pathophysiology, and mechanisms of pruritus of major systemic underlying diseases, including end-stage renal disease, cholestatic liver disease, endocrine/metabolic diseases, and hematologic/lymphoproliferative diseases.
AB - Pruritus is a sensation that emanates from the skin and is transferred through peripheral nerve fibers to the central nervous system. It is easily understood that primary skin disorders, such as atopic eczema, skin dryness, psoriasis, and urticaria, can elicit pruritus. However, certain systemic diseases can cause chronic pruritus, which has a significant effect on the patient's quality of life. In this rostrum we provide an overview of the characteristics, pathophysiology, and mechanisms of pruritus of major systemic underlying diseases, including end-stage renal disease, cholestatic liver disease, endocrine/metabolic diseases, and hematologic/lymphoproliferative diseases.
KW - Itch
KW - pruritus
KW - systemic disease
UR - http://www.scopus.com/inward/record.url?scp=85065532610&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85065532610&partnerID=8YFLogxK
U2 - 10.1016/j.jaci.2019.04.005
DO - 10.1016/j.jaci.2019.04.005
M3 - Article
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
SN - 0091-6749
ER -