Itching as a systemic disease

Takashi Hashimoto, Gil Yosipovitch

Research output: Contribution to journalArticle

Abstract

Pruritus is a sensation that emanates from the skin and is transferred through peripheral nerve fibers to the central nervous system. It is easily understood that primary skin disorders, such as atopic eczema, skin dryness, psoriasis, and urticaria, can elicit pruritus. However, certain systemic diseases can cause chronic pruritus, which has a significant effect on the patient's quality of life. In this rostrum we provide an overview of the characteristics, pathophysiology, and mechanisms of pruritus of major systemic underlying diseases, including end-stage renal disease, cholestatic liver disease, endocrine/metabolic diseases, and hematologic/lymphoproliferative diseases.

Original languageEnglish (US)
JournalJournal of Allergy and Clinical Immunology
DOIs
StatePublished - Jan 1 2019

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Pruritus
Skin
Endocrine System Diseases
Hematologic Diseases
Metabolic Diseases
Urticaria
Atopic Dermatitis
Peripheral Nerves
Nerve Fibers
Psoriasis
Chronic Kidney Failure
Liver Diseases
Central Nervous System
Quality of Life

Keywords

  • Itch
  • pruritus
  • systemic disease

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Itching as a systemic disease. / Hashimoto, Takashi; Yosipovitch, Gil.

In: Journal of Allergy and Clinical Immunology, 01.01.2019.

Research output: Contribution to journalArticle

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