Itching as a systemic disease

Takashi Hashimoto; Gil Yosipovitch

doi:10.1016/j.jaci.2019.04.005

Itching as a systemic disease

Takashi Hashimoto, Gil Yosipovitch

Dermatology & Cutaneous Surgery

Research output: Contribution to journal › Article

11 Scopus citations

Abstract

Pruritus is a sensation that emanates from the skin and is transferred through peripheral nerve fibers to the central nervous system. It is easily understood that primary skin disorders, such as atopic eczema, skin dryness, psoriasis, and urticaria, can elicit pruritus. However, certain systemic diseases can cause chronic pruritus, which has a significant effect on the patient's quality of life. In this rostrum we provide an overview of the characteristics, pathophysiology, and mechanisms of pruritus of major systemic underlying diseases, including end-stage renal disease, cholestatic liver disease, endocrine/metabolic diseases, and hematologic/lymphoproliferative diseases.

Original language	English (US)
Journal	Journal of Allergy and Clinical Immunology
DOIs	https://doi.org/10.1016/j.jaci.2019.04.005
State	Published - Jan 1 2019

Keywords

Itch
pruritus
systemic disease

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.jaci.2019.04.005

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Hashimoto, T., & Yosipovitch, G. (2019). Itching as a systemic disease. Journal of Allergy and Clinical Immunology. https://doi.org/10.1016/j.jaci.2019.04.005

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