Issues in implementing prenatal screening for cystic fibrosis: Results of a working conference

James E. Haddow, Linda A. Bradley, Glenn E. Palomaki, Richard A. Doherty, Barbara A. Bernhardt, David J.H. Brock, Brian Cheuvront, George C. Cunningham, Alan E. Donnenfeld, Jeryl L. Erickson, Henry A. Erlich, Richard M. Ferrie, Stacey C. Fitzsimmons, Michael F. Greene, Wayne W. Grody, Paula K. Haddow, Hilary Harris, Lewis B. Holmes, R. Rodney Howell, Michael KatzKatherine W. Klinger, Edward M. Kloza, Michael L. Lefevre, Stephen Little, Greg Loeben, Margaret McGovern, Reed E. Pyeritz, Peter T. Rowley, Randall K. Saiki, M. Priscilla Short, John Tabone, Nicholas J. Wald, Nachama L. Wilker, David R. Witt

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Purpose: To summarize a conference convened to examine how cystic fibrosis screening might appropriately be introduced into routine prenatal practice. Methods: Participants included experts from various relevant disciplines. Systematic reviews and data from individual trials were presented; issues were identified and discussed. Results: Judged by published criteria, prenatal cystic fibrosis screening is suitable for introduction. Screening can be performed cost-effectively by identifying racial/ethnic groups at sufficient risk and then using either of two models for delivering laboratory services. Validated educational materials exist. Ethical issues are not unique. Conclusions: Once adequate facilities for patient and provider education, testing, counseling, quality control, and monitoring are in place, individual programs can begin prenatal screening for cystic fibrosis.

Original languageEnglish (US)
Pages (from-to)129-135
Number of pages7
JournalGenetics in Medicine
Issue number4
StatePublished - 1999


  • Cystic fibrosis
  • Genetic testing
  • Prenatal
  • Screening

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics


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