Issues in designing and implementing a Spanish-language multi-site clinical trial

Lourdes Suarez-Morales, Julie Matthews, Steve Martino, Samuel A. Ball, Carmen Rosa, Christine Farentinos, José Szapocznik, Kathleen M. Carroll

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


To address at least in part health disparities in Hispanic populations, the NIDA Clinical Trials Network implemented the first multi-site randomized clinical trial of substance abuse treatment conducted entirely in Spanish. This trial was intended to evaluate the effectiveness of Motivational Enhancement Therapy in a diverse population of Hispanics. In the conduct of this trial, several barriers to the successful implementation of a Spanish-language multi-site trial had to be addressed, including the appropriate translation of assessment instruments, shortage of appropriately trained Spanish-speaking clinical staff, and barriers to recruitment and retention of this population. To encourage similar research, strategies are described that were developed by the study team to meet these challenges.

Original languageEnglish (US)
Pages (from-to)206-215
Number of pages10
JournalAmerican Journal on Addictions
Issue number3
StatePublished - May 2007

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Clinical Psychology
  • Psychiatry and Mental health


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