Isolation of T-cell tropic HTLV-III-like retrovirus from macaques

M. D. Daniel, N. L. Letvin, N. W. King, M. Kannagi, P. K. Sehgal, R. D. Hunt, P. J. Kanki, M. Essex, Ronald Charles Desrosiers

Research output: Contribution to journalArticle

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Abstract

The isolation of a T-cell tropic retrovirus from three immunodeficient macaques and one macaque with lymphoma is described. The morphology, growth characteristics, and antigenic properties of this virus indicate that it is related to the causative agent of acquired immune deficiency syndrome in humans (HTLV-III or LAV). This virus is referred to as simian T-lymphotropic virus type III (STLV-III) of macaques. The existence of a cytopathic, T-cell tropic virus resembling HTLV-III in monkeys may facilitate study of disease induction and vaccine development in an animal model.

Original languageEnglish (US)
Pages (from-to)1201-1204
Number of pages4
JournalScience
Volume228
Issue number4704
DOIs
StatePublished - 1985
Externally publishedYes

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Macaca
Retroviridae
HIV
Viruses
T-Lymphocytes
Haplorhini
Lymphoma
Acquired Immunodeficiency Syndrome
Vaccines
Animal Models
Growth

ASJC Scopus subject areas

  • General

Cite this

Daniel, M. D., Letvin, N. L., King, N. W., Kannagi, M., Sehgal, P. K., Hunt, R. D., ... Desrosiers, R. C. (1985). Isolation of T-cell tropic HTLV-III-like retrovirus from macaques. Science, 228(4704), 1201-1204. https://doi.org/10.1126/science.3159089

Isolation of T-cell tropic HTLV-III-like retrovirus from macaques. / Daniel, M. D.; Letvin, N. L.; King, N. W.; Kannagi, M.; Sehgal, P. K.; Hunt, R. D.; Kanki, P. J.; Essex, M.; Desrosiers, Ronald Charles.

In: Science, Vol. 228, No. 4704, 1985, p. 1201-1204.

Research output: Contribution to journalArticle

Daniel, MD, Letvin, NL, King, NW, Kannagi, M, Sehgal, PK, Hunt, RD, Kanki, PJ, Essex, M & Desrosiers, RC 1985, 'Isolation of T-cell tropic HTLV-III-like retrovirus from macaques', Science, vol. 228, no. 4704, pp. 1201-1204. https://doi.org/10.1126/science.3159089
Daniel MD, Letvin NL, King NW, Kannagi M, Sehgal PK, Hunt RD et al. Isolation of T-cell tropic HTLV-III-like retrovirus from macaques. Science. 1985;228(4704):1201-1204. https://doi.org/10.1126/science.3159089
Daniel, M. D. ; Letvin, N. L. ; King, N. W. ; Kannagi, M. ; Sehgal, P. K. ; Hunt, R. D. ; Kanki, P. J. ; Essex, M. ; Desrosiers, Ronald Charles. / Isolation of T-cell tropic HTLV-III-like retrovirus from macaques. In: Science. 1985 ; Vol. 228, No. 4704. pp. 1201-1204.
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