Isolation of T-cell tropic HTLV-III-like retrovirus from macaques

M. D. Daniel, N. L. Letvin, N. W. King, M. Kannagi, P. K. Sehgal, R. D. Hunt, P. J. Kanki, M. Essex, R. C. Desrosiers

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Abstract

The isolation of a T-cell tropic retrovirus from three immunodeficient macaques and one macaque with lymphoma is described. The morphology, growth characteristics, and antigenic properties of this virus indicate that it is related to the causative agent of acquired immune deficiency syndrome in humans (HTLV-III or LAV). This virus is referred to as simian T-lymphotropic virus type III (STLV-III) of macaques. The existence of a cytopathic, T-cell tropic virus resembling HTLV-III in monkeys may facilitate study of disease induction and vaccine development in an animal model.

Original languageEnglish (US)
Pages (from-to)1201-1204
Number of pages4
JournalScience
Volume228
Issue number4704
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

ASJC Scopus subject areas

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    Daniel, M. D., Letvin, N. L., King, N. W., Kannagi, M., Sehgal, P. K., Hunt, R. D., Kanki, P. J., Essex, M., & Desrosiers, R. C. (1985). Isolation of T-cell tropic HTLV-III-like retrovirus from macaques. Science, 228(4704), 1201-1204. https://doi.org/10.1126/science.3159089