Isolation of a guanylate cyclase inhibitor from the balsam pear (Momordica charantia abreviata)

David L. Vesely, William R. Graves, Timothy M. Lo, Mary Ann Fletcher, Gerald S. Levey

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The balsam pear (Momordica charantia abreviata) is a plant which grows wild throughout subtropical regions including the Gulf Coast and Florida. The ripe fruit is highly toxic and produces mild hypoglycemia. Preparations of the ripe fruit and the leaves but not the unripe fruit or seeds inhibited guanylate cyclase activity whereas adenylate cyclase activity was unaffected. The guanylate cyclase inhibitor (GCI) has been purified about 30-fold has an estimated molecular weight of 5000 to 50,000 and is acid stable and heat labile. GCI blocked the activation of guanylate cyclase by nitroso chemical carcinogens, and therefore, may be useful in studying mechanisms of chemical carcinogenesis.

Original languageEnglish
Pages (from-to)1294-1299
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume77
Issue number4
DOIs
StatePublished - Aug 22 1977
Externally publishedYes

Fingerprint

Balsams
Momordica charantia
Pyrus
Guanylate Cyclase
Fruits
Fruit
Poisons
Hypoglycemia
Adenylyl Cyclases
Carcinogens
Coastal zones
Seed
Seeds
Carcinogenesis
Hot Temperature
Molecular Weight
Chemical activation
Molecular weight
Acids

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Isolation of a guanylate cyclase inhibitor from the balsam pear (Momordica charantia abreviata). / Vesely, David L.; Graves, William R.; Lo, Timothy M.; Fletcher, Mary Ann; Levey, Gerald S.

In: Biochemical and Biophysical Research Communications, Vol. 77, No. 4, 22.08.1977, p. 1294-1299.

Research output: Contribution to journalArticle

Vesely, David L. ; Graves, William R. ; Lo, Timothy M. ; Fletcher, Mary Ann ; Levey, Gerald S. / Isolation of a guanylate cyclase inhibitor from the balsam pear (Momordica charantia abreviata). In: Biochemical and Biophysical Research Communications. 1977 ; Vol. 77, No. 4. pp. 1294-1299.
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