Isolation and structure of several peptides from porcine hypothalami

Robert C.C. Chang, Wei Yong Huang, Tommie W. Redding, Akira Arimura, David H. Coy, Andrew V. Schally

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Ten peptides were isolated from porcine hypothalami and structurally elucidated. These included four dipeptides Arg-Phe, Phe-Tyr, Val-Trp, and Tyr-Phe; a tripeptide Lys-Phe-Tyr; two tetrapeptides Gly-Lys-Val-Asn and Phe-Glu-His-Glu, a nonapeptide Val-Val-Tyr-Pro-Trp-Thr-Gln-Arg-Phe; a decapeptide Leu-Val-Val-Tyr-Pro-Trp-Thr-Gln-Arg-Phe and a hexadecapeptide Phe-Leu-gly-Phe-Pro-Thr-Thr-Lys-Thr-Tyr-Phe-Pro-His-Phe-Asn-Leu. The tetrapeptide Gly-Lys-Val-Asn, the nonapeptide, the decapeptide and the hexadecapeptide most probably represent artifact fragments of α- and β-chains of porcine hemoglobin. The natural or synthetic Gly-Lys-Val-Asn and Phe-Glu-His-Glu had some growth hormone releasing activity while Val-Trp, Tyr-Phe and Lys-Phe-Tyr had slight prolactin releasing activity. The biological activities of other peptides have not been determined yet.

Original languageEnglish (US)
Pages (from-to)266-273
Number of pages8
JournalUnknown Journal
Volume625
Issue number2
DOIs
StatePublished - Jan 1 1980
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology

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    Chang, R. C. C., Huang, W. Y., Redding, T. W., Arimura, A., Coy, D. H., & Schally, A. V. (1980). Isolation and structure of several peptides from porcine hypothalami. Unknown Journal, 625(2), 266-273. https://doi.org/10.1016/0005-2795(80)90290-1