Isolation and structure of several peptides from porcine hypothalami

R. C C Chang, W. Y. Huang, T. W. Redding, A. Arimura, D. H. Coy, Andrew V Schally

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Ten peptides were isolated from porcine hypothalami and structurally elucidated. These included four dipeptides Arg-Phe, Phe-Tyr, Val-Trp, and Tyr-Phe; a tripeptide Lys-Phe-Tyr; two tetrapeptides Gly-Lys-Val-Asn and Phe-Glu-His-Glu, a nonapeptide Val-Val-Tyr-Pro-Trp-Thr-Gln-Arg-Phe; a decapeptide Leu-Val-Val-Tyr-Pro-Trp-Thr-Gln-Arg-Phe and a hexadecapeptide Phe-Leu-gly-Phe-Pro-Thr-Thr-Lys-Thr-Tyr-Phe-Pro-His-Phe-Asn-Leu. The tetrapeptide Gly-Lys-Val-Asn, the nonapeptide, the decapeptide and the hexadecapeptide most probably represent artifact fragments of α- and β-chains of porcine hemoglobin. The natural or synthetic Gly-Lys-Val-Asn and Phe-Glu-His-Glu had some growth hormone releasing activity while Val-Trp, Tyr-Phe and Lys-Phe-Tyr had slight prolactin releasing activity. The biological activities of other peptides have not been determined yet.

Original languageEnglish
Pages (from-to)266-273
Number of pages8
JournalBiochimica et Biophysica Acta
Volume625
Issue number2
DOIs
StatePublished - Dec 1 1980
Externally publishedYes

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N-valyltryptophan
VV-hemorphin-7
LVV-hemorphin-7
Hypothalamus
Swine
Peptides
Dipeptides
Bioactivity
Prolactin
Artifacts
Growth Hormone
Hemoglobins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Isolation and structure of several peptides from porcine hypothalami. / Chang, R. C C; Huang, W. Y.; Redding, T. W.; Arimura, A.; Coy, D. H.; Schally, Andrew V.

In: Biochimica et Biophysica Acta, Vol. 625, No. 2, 01.12.1980, p. 266-273.

Research output: Contribution to journalArticle

Chang, R. C C ; Huang, W. Y. ; Redding, T. W. ; Arimura, A. ; Coy, D. H. ; Schally, Andrew V. / Isolation and structure of several peptides from porcine hypothalami. In: Biochimica et Biophysica Acta. 1980 ; Vol. 625, No. 2. pp. 266-273.
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