Isolation and structure of pro-somatostatin: a putative somatostatin precursor from pig hypothalamus.

A. V. Schally, W. Y. Huang, R. C. Chang, A. Arimura, T. W. Redding, R. P. Millar, M. W. Hunkapiller, L. E. Hood

Research output: Contribution to journalArticle

162 Scopus citations

Abstract

An octacosapeptide that we named pro-somatostatin has been isolated from acid extracts of porcine hypothalami and found to have the amino acid sequence Ser-Ala-Asn-Ser-Asn-Pro-Ala-Met-Ala-Pro-Arg-Glu-Arg-Lys-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys. This octacosapeptide possesses high somatotropin (growth hormone) and prolactin release-inhibiting activity in vitro. It also crossreacts strongly with antisera generated against the somatostatin tetradecapeptide. This octacosapeptide is most likely a precursor (pro-hormone) of somatostatin in the hypothalamus. The existence of still larger molecular size precursors of somatostatin was also observed.

Original languageEnglish (US)
Pages (from-to)4489-4493
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume77
Issue number8
DOIs
StatePublished - Aug 1980

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Isolation and structure of pro-somatostatin: a putative somatostatin precursor from pig hypothalamus.'. Together they form a unique fingerprint.

Cite this