Isolation and structure of pro-somatostatin: a putative somatostatin precursor from pig hypothalamus.

A. V. Schally, W. Y. Huang, R. C. Chang, A. Arimura, T. W. Redding, R. P. Millar, M. W. Hunkapiller, L. E. Hood

Research output: Contribution to journalArticle

162 Scopus citations


An octacosapeptide that we named pro-somatostatin has been isolated from acid extracts of porcine hypothalami and found to have the amino acid sequence Ser-Ala-Asn-Ser-Asn-Pro-Ala-Met-Ala-Pro-Arg-Glu-Arg-Lys-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys. This octacosapeptide possesses high somatotropin (growth hormone) and prolactin release-inhibiting activity in vitro. It also crossreacts strongly with antisera generated against the somatostatin tetradecapeptide. This octacosapeptide is most likely a precursor (pro-hormone) of somatostatin in the hypothalamus. The existence of still larger molecular size precursors of somatostatin was also observed.

Original languageEnglish (US)
Pages (from-to)4489-4493
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number8
StatePublished - Aug 1980
Externally publishedYes


ASJC Scopus subject areas

  • General

Cite this