Isolation and properties of the FSH and LH-releasing hormone

Andrew V Schally, A. Arimura, Y. Baba, R. M G Nair, H. Matsuo, T. W. Redding, L. Debeljuk, W. F. White

Research output: Contribution to journalArticle

446 Citations (Scopus)

Abstract

LH-releasing hormone (LH-RH) was obtained in apparently a homogeneous state from extracts of pig hypothalami. The LH-RH preparation isolated has FSH-releasing hormone (FSH-RH) activity, which appears to be intrinsic to LH-RH. The amino acid composition of LH-RH/FSH-RH as determined on acid hydrolysates is: His 1, Arg 1, Ser 1, Glu 1, Pro 1, Gly 2, Leu 1 and Tyr 1. The hormone isolated stimulates the release of FSH and LH in vivo and in vitro in doses of a few nanograms. This polypeptide appears to represent the hypothalamic hormone which controls the secretion of both LH and FSH from the pituitary.

Original languageEnglish
Pages (from-to)393-399
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume43
Issue number2
DOIs
StatePublished - Apr 16 1971
Externally publishedYes

Fingerprint

Gonadotropin-Releasing Hormone
Hypothalamic Hormones
Hypothalamus
Hormones
Swine
Amino Acids
Peptides
Acids
Chemical analysis

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Schally, A. V., Arimura, A., Baba, Y., Nair, R. M. G., Matsuo, H., Redding, T. W., ... White, W. F. (1971). Isolation and properties of the FSH and LH-releasing hormone. Biochemical and Biophysical Research Communications, 43(2), 393-399. https://doi.org/10.1016/0006-291X(71)90766-2

Isolation and properties of the FSH and LH-releasing hormone. / Schally, Andrew V; Arimura, A.; Baba, Y.; Nair, R. M G; Matsuo, H.; Redding, T. W.; Debeljuk, L.; White, W. F.

In: Biochemical and Biophysical Research Communications, Vol. 43, No. 2, 16.04.1971, p. 393-399.

Research output: Contribution to journalArticle

Schally, AV, Arimura, A, Baba, Y, Nair, RMG, Matsuo, H, Redding, TW, Debeljuk, L & White, WF 1971, 'Isolation and properties of the FSH and LH-releasing hormone', Biochemical and Biophysical Research Communications, vol. 43, no. 2, pp. 393-399. https://doi.org/10.1016/0006-291X(71)90766-2
Schally, Andrew V ; Arimura, A. ; Baba, Y. ; Nair, R. M G ; Matsuo, H. ; Redding, T. W. ; Debeljuk, L. ; White, W. F. / Isolation and properties of the FSH and LH-releasing hormone. In: Biochemical and Biophysical Research Communications. 1971 ; Vol. 43, No. 2. pp. 393-399.
@article{400ac378507f4168b1c85c968ea6b7b0,
title = "Isolation and properties of the FSH and LH-releasing hormone",
abstract = "LH-releasing hormone (LH-RH) was obtained in apparently a homogeneous state from extracts of pig hypothalami. The LH-RH preparation isolated has FSH-releasing hormone (FSH-RH) activity, which appears to be intrinsic to LH-RH. The amino acid composition of LH-RH/FSH-RH as determined on acid hydrolysates is: His 1, Arg 1, Ser 1, Glu 1, Pro 1, Gly 2, Leu 1 and Tyr 1. The hormone isolated stimulates the release of FSH and LH in vivo and in vitro in doses of a few nanograms. This polypeptide appears to represent the hypothalamic hormone which controls the secretion of both LH and FSH from the pituitary.",
author = "Schally, {Andrew V} and A. Arimura and Y. Baba and Nair, {R. M G} and H. Matsuo and Redding, {T. W.} and L. Debeljuk and White, {W. F.}",
year = "1971",
month = "4",
day = "16",
doi = "10.1016/0006-291X(71)90766-2",
language = "English",
volume = "43",
pages = "393--399",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Isolation and properties of the FSH and LH-releasing hormone

AU - Schally, Andrew V

AU - Arimura, A.

AU - Baba, Y.

AU - Nair, R. M G

AU - Matsuo, H.

AU - Redding, T. W.

AU - Debeljuk, L.

AU - White, W. F.

PY - 1971/4/16

Y1 - 1971/4/16

N2 - LH-releasing hormone (LH-RH) was obtained in apparently a homogeneous state from extracts of pig hypothalami. The LH-RH preparation isolated has FSH-releasing hormone (FSH-RH) activity, which appears to be intrinsic to LH-RH. The amino acid composition of LH-RH/FSH-RH as determined on acid hydrolysates is: His 1, Arg 1, Ser 1, Glu 1, Pro 1, Gly 2, Leu 1 and Tyr 1. The hormone isolated stimulates the release of FSH and LH in vivo and in vitro in doses of a few nanograms. This polypeptide appears to represent the hypothalamic hormone which controls the secretion of both LH and FSH from the pituitary.

AB - LH-releasing hormone (LH-RH) was obtained in apparently a homogeneous state from extracts of pig hypothalami. The LH-RH preparation isolated has FSH-releasing hormone (FSH-RH) activity, which appears to be intrinsic to LH-RH. The amino acid composition of LH-RH/FSH-RH as determined on acid hydrolysates is: His 1, Arg 1, Ser 1, Glu 1, Pro 1, Gly 2, Leu 1 and Tyr 1. The hormone isolated stimulates the release of FSH and LH in vivo and in vitro in doses of a few nanograms. This polypeptide appears to represent the hypothalamic hormone which controls the secretion of both LH and FSH from the pituitary.

UR - http://www.scopus.com/inward/record.url?scp=0015228709&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015228709&partnerID=8YFLogxK

U2 - 10.1016/0006-291X(71)90766-2

DO - 10.1016/0006-291X(71)90766-2

M3 - Article

C2 - 4930860

AN - SCOPUS:0015228709

VL - 43

SP - 393

EP - 399

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

IS - 2

ER -