Isolation and properties of the FSH and LH-releasing hormone

A. V. Schally, A. Arimura, Y. Baba, R. M.G. Nair, H. Matsuo, T. W. Redding, L. Debeljuk, W. F. White

Research output: Contribution to journalArticle

449 Scopus citations

Abstract

LH-releasing hormone (LH-RH) was obtained in apparently a homogeneous state from extracts of pig hypothalami. The LH-RH preparation isolated has FSH-releasing hormone (FSH-RH) activity, which appears to be intrinsic to LH-RH. The amino acid composition of LH-RH/FSH-RH as determined on acid hydrolysates is: His 1, Arg 1, Ser 1, Glu 1, Pro 1, Gly 2, Leu 1 and Tyr 1. The hormone isolated stimulates the release of FSH and LH in vivo and in vitro in doses of a few nanograms. This polypeptide appears to represent the hypothalamic hormone which controls the secretion of both LH and FSH from the pituitary.

Original languageEnglish (US)
Pages (from-to)393-399
Number of pages7
JournalBiochemical and biophysical research communications
Volume43
Issue number2
DOIs
StatePublished - Apr 16 1971
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Schally, A. V., Arimura, A., Baba, Y., Nair, R. M. G., Matsuo, H., Redding, T. W., Debeljuk, L., & White, W. F. (1971). Isolation and properties of the FSH and LH-releasing hormone. Biochemical and biophysical research communications, 43(2), 393-399. https://doi.org/10.1016/0006-291X(71)90766-2