Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease

David Y. Huang; Michel Goedert; Ross Jakes; Karl H. Weisgraber; Craig C. Garner; Ann M. Saunders; Margaret A. Pericak-Vance; Donald E. Schmechel; Allen D. Roses; Warren J. Strittmatter

doi:10.1016/0304-3940(94)90204-6

Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease

David Y. Huang, Michel Goedert, Ross Jakes, Karl H. Weisgraber, Craig C. Garner, Ann M. Saunders, Margaret A. Pericak-Vance, Donald E. Schmechel, Allen D. Roses, Warren J. Strittmatter

Research output: Contribution to journal › Article › peer-review

72 Scopus citations

Abstract

The apolipoprotein E type 4 allele is a susceptibility gene for late-onset Alzheimer's disease. Apolipoprotein E is found in neurons, some of which contain paired helical filaments made of the microtubule-associated protein τ. Previous studies have demonstrated that the apoE3 isoform, but not the apoE4 isoform, binds τ with high avidity. Because the microtubule-associated protein MAP2c also effects microtubule assembly and stability, we examined interactions between apoE isoforms and MAP2c. Similar to the τ-binding results, apoE3, but not apoE4, bound MAP2c. Binding was detectable down to 10^-9 M MAP2c and 10^-8 M apoE3. Isoform-specific interactions of apoE with the microtubule-associated proteins MAP2c and τ might affect intracellular maintenance of microtubules and could contribute to a time-dependent pathogenesis of Alzheimer's disease.

Original language	English (US)
Pages (from-to)	55-58
Number of pages	4
Journal	Neuroscience Letters
Volume	182
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(94)90204-6
State	Published - Nov 21 1994
Externally published	Yes

Keywords

Alzheimer's disease
Apolipoprotein E
MAP2c
Microtubule-associated protein

ASJC Scopus subject areas

Neuroscience(all)

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Huang, D. Y., Goedert, M., Jakes, R., Weisgraber, K. H., Garner, C. C., Saunders, A. M., Pericak-Vance, M. A., Schmechel, D. E., Roses, A. D., & Strittmatter, W. J. (1994). Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease. Neuroscience Letters, 182(1), 55-58. https://doi.org/10.1016/0304-3940(94)90204-6

Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c : implications for Alzheimer's disease. / Huang, David Y.; Goedert, Michel; Jakes, Ross; Weisgraber, Karl H.; Garner, Craig C.; Saunders, Ann M.; Pericak-Vance, Margaret A.; Schmechel, Donald E.; Roses, Allen D.; Strittmatter, Warren J.

In: Neuroscience Letters, Vol. 182, No. 1, 21.11.1994, p. 55-58.

Research output: Contribution to journal › Article › peer-review

Huang, DY, Goedert, M, Jakes, R, Weisgraber, KH, Garner, CC, Saunders, AM, Pericak-Vance, MA, Schmechel, DE, Roses, AD & Strittmatter, WJ 1994, 'Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease', Neuroscience Letters, vol. 182, no. 1, pp. 55-58. https://doi.org/10.1016/0304-3940(94)90204-6

Huang, David Y. ; Goedert, Michel ; Jakes, Ross ; Weisgraber, Karl H. ; Garner, Craig C. ; Saunders, Ann M. ; Pericak-Vance, Margaret A. ; Schmechel, Donald E. ; Roses, Allen D. ; Strittmatter, Warren J. / Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c : implications for Alzheimer's disease. In: Neuroscience Letters. 1994 ; Vol. 182, No. 1. pp. 55-58.

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title = "Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease",

abstract = "The apolipoprotein E type 4 allele is a susceptibility gene for late-onset Alzheimer's disease. Apolipoprotein E is found in neurons, some of which contain paired helical filaments made of the microtubule-associated protein τ. Previous studies have demonstrated that the apoE3 isoform, but not the apoE4 isoform, binds τ with high avidity. Because the microtubule-associated protein MAP2c also effects microtubule assembly and stability, we examined interactions between apoE isoforms and MAP2c. Similar to the τ-binding results, apoE3, but not apoE4, bound MAP2c. Binding was detectable down to 10-9 M MAP2c and 10-8 M apoE3. Isoform-specific interactions of apoE with the microtubule-associated proteins MAP2c and τ might affect intracellular maintenance of microtubules and could contribute to a time-dependent pathogenesis of Alzheimer's disease.",

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AB - The apolipoprotein E type 4 allele is a susceptibility gene for late-onset Alzheimer's disease. Apolipoprotein E is found in neurons, some of which contain paired helical filaments made of the microtubule-associated protein τ. Previous studies have demonstrated that the apoE3 isoform, but not the apoE4 isoform, binds τ with high avidity. Because the microtubule-associated protein MAP2c also effects microtubule assembly and stability, we examined interactions between apoE isoforms and MAP2c. Similar to the τ-binding results, apoE3, but not apoE4, bound MAP2c. Binding was detectable down to 10-9 M MAP2c and 10-8 M apoE3. Isoform-specific interactions of apoE with the microtubule-associated proteins MAP2c and τ might affect intracellular maintenance of microtubules and could contribute to a time-dependent pathogenesis of Alzheimer's disease.

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Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

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