Isoform diversity and its importance for axon regeneration

Jessica K. Lerch, John L. Bixby, Vance P. Lemmon

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Axon regeneration is a fundamental problem facing neuroscientists and clinicians. Failure of axon regeneration is caused by both extrinsic and intrinsic mechanisms. New techniques to examine gene expression such as Next Generation Sequencing of the Transcriptome (RNA-Seq) drastically increase our knowledge of both gene expression complexity (RNA isoforms) and gene expression regulation. By utilizing RNA-Seq, gene expression can now be defined at the level of isoforms, an essential step for understanding the mechanisms governing cell identity, growth and ultimately cellular responses to injury and disease.

Original languageEnglish (US)
Pages (from-to)420-431
Number of pages12
JournalNeuropathology
Volume32
Issue number4
DOIs
StatePublished - Aug 2012

Keywords

  • Axon
  • Isoform
  • Promoter
  • Regeneration
  • RNA-Seq

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology

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