Islet transplantation: Immunological perspectives

Luca A Inverardi, Norma S Kenyon, Camillo Ricordi

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Clinical trials of islet transplantation are showing remarkable success, but they require administration of chronic immunosuppression, and are underscoring the large gap that exists between the number of human donors available and the number of patients that could benefit from the procedure. Recent progress has been made in the definition of key immunological mechanisms that are involved in determining islet transplant outcome. Clinical and preclinical studies, and studies in small animal model systems, will all eventually contribute to the definition of efficient and safe protocols for islet transplantation. If the use of xenografts is successful, it might represent a solution to the shortage of human organs.

Original languageEnglish
Pages (from-to)507-511
Number of pages5
JournalCurrent Opinion in Immunology
Volume15
Issue number5
DOIs
StatePublished - Oct 1 2003

Fingerprint

Islets of Langerhans Transplantation
Heterografts
Immunosuppression
Animal Models
Tissue Donors
Clinical Trials
Transplants
Clinical Studies

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Islet transplantation : Immunological perspectives. / Inverardi, Luca A; Kenyon, Norma S; Ricordi, Camillo.

In: Current Opinion in Immunology, Vol. 15, No. 5, 01.10.2003, p. 507-511.

Research output: Contribution to journalArticle

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