Islet product characteristics and factors related to successful human islet transplantation from the collaborative islet transplant registry (CITR) 1999-2010

A. N. Balamurugan, B. Naziruddin, A. Lockridge, M. Tiwari, G. Loganathan, M. Takita, S. Matsumoto, K. Papas, M. Trieger, H. Rainis, T. Kin, T. W. Kay, S. Wease, Shari Messinger, Camillo Ricordi, Rodolfo Alejandro, J. Markmann, J. Kerr-Conti, M. R. Rickels, C. LiuX. Zhang, P. Witkowski, A. Posselt, P. Maffi, A. Secchi, T. Berney, P. J. O'Connell, B. J. Hering, F. B. Barton

Research output: Contribution to journalArticle

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Abstract

The Collaborative Islet Transplant Registry (CITR) collects data on clinical islet isolations and transplants. This retrospective report analyzed 1017 islet isolation procedures performed for 537 recipients of allogeneic clinical islet transplantation in 1999-2010. This study describes changes in donor and islet isolation variables by era and factors associated with quantity and quality of final islet products. Donor body weight and BMI increased significantly over the period (p < 0.001). Islet yield measures have improved with time including islet equivalent (IEQ)/particle ratio and IEQs infused. The average dose of islets infused significantly increased in the era of 2007-2010 when compared to 1999-2002 (445.4 ± 156.8 vs. 421.3 ± 155.4 ×103 IEQ; p < 0.05). Islet purity and total number of β cells significantly improved over the study period (p < 0.01 and <0.05, respectively). Otherwise, the quality of clinical islets has remained consistently very high through this period, and differs substantially from nonclinical islets. In multivariate analysis of all recipient, donor and islet factors, and medical management factors, the only islet product characteristic that correlated with clinical outcomes was total IEQs infused. This analysis shows improvements in both quantity and some quality criteria of clinical islets produced over 1999-2010, and these parallel improvements in clinical outcomes over the same period. Product criteria from clinical grade allogeneic human islets exhibit consistently superior-quality characteristics and significantly increasing islet equivalent yield, paralleling improving success rates of islet transplantation for type I diabetes.

Original languageEnglish
Pages (from-to)2595-2606
Number of pages12
JournalAmerican Journal of Transplantation
Volume14
Issue number11
DOIs
StatePublished - Jan 1 2014

Fingerprint

Islets of Langerhans Transplantation
Registries
Transplants
Type 1 Diabetes Mellitus
Multivariate Analysis
Cell Count
Body Weight

Keywords

  • Clinical research/practice
  • diabetes: type 1
  • endocrinology/diabetology
  • health services and outcomes research
  • islet isolation
  • islet transplantation
  • Organ Procurement and Transplantation Network (OPTN)
  • pancreas/simultaneous pancreas-kidney transplantation
  • registry/registry analysis

ASJC Scopus subject areas

  • Transplantation
  • Immunology and Allergy
  • Pharmacology (medical)

Cite this

Islet product characteristics and factors related to successful human islet transplantation from the collaborative islet transplant registry (CITR) 1999-2010. / Balamurugan, A. N.; Naziruddin, B.; Lockridge, A.; Tiwari, M.; Loganathan, G.; Takita, M.; Matsumoto, S.; Papas, K.; Trieger, M.; Rainis, H.; Kin, T.; Kay, T. W.; Wease, S.; Messinger, Shari; Ricordi, Camillo; Alejandro, Rodolfo; Markmann, J.; Kerr-Conti, J.; Rickels, M. R.; Liu, C.; Zhang, X.; Witkowski, P.; Posselt, A.; Maffi, P.; Secchi, A.; Berney, T.; O'Connell, P. J.; Hering, B. J.; Barton, F. B.

In: American Journal of Transplantation, Vol. 14, No. 11, 01.01.2014, p. 2595-2606.

Research output: Contribution to journalArticle

Balamurugan, AN, Naziruddin, B, Lockridge, A, Tiwari, M, Loganathan, G, Takita, M, Matsumoto, S, Papas, K, Trieger, M, Rainis, H, Kin, T, Kay, TW, Wease, S, Messinger, S, Ricordi, C, Alejandro, R, Markmann, J, Kerr-Conti, J, Rickels, MR, Liu, C, Zhang, X, Witkowski, P, Posselt, A, Maffi, P, Secchi, A, Berney, T, O'Connell, PJ, Hering, BJ & Barton, FB 2014, 'Islet product characteristics and factors related to successful human islet transplantation from the collaborative islet transplant registry (CITR) 1999-2010', American Journal of Transplantation, vol. 14, no. 11, pp. 2595-2606. https://doi.org/10.1111/ajt.12872
Balamurugan, A. N. ; Naziruddin, B. ; Lockridge, A. ; Tiwari, M. ; Loganathan, G. ; Takita, M. ; Matsumoto, S. ; Papas, K. ; Trieger, M. ; Rainis, H. ; Kin, T. ; Kay, T. W. ; Wease, S. ; Messinger, Shari ; Ricordi, Camillo ; Alejandro, Rodolfo ; Markmann, J. ; Kerr-Conti, J. ; Rickels, M. R. ; Liu, C. ; Zhang, X. ; Witkowski, P. ; Posselt, A. ; Maffi, P. ; Secchi, A. ; Berney, T. ; O'Connell, P. J. ; Hering, B. J. ; Barton, F. B. / Islet product characteristics and factors related to successful human islet transplantation from the collaborative islet transplant registry (CITR) 1999-2010. In: American Journal of Transplantation. 2014 ; Vol. 14, No. 11. pp. 2595-2606.
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