Islet isolation for autotransplantation, following total or near total pancreatectomy

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Human islet isolation for autotransplantation (IAT) is performed to prevent surgically induced diabetes following near total or total pancreatectomy. The latter is performed to alleviate intractable pain and suffering, and prolong life in patients suffering from chronic pancreatitis. Since 1997, when it was first performed at the University of Minnesota, islet isolation for IAT following pancreatic resection has been demonstrated as the best option to improve pain, alleviate the risk of “brittle diabetes, " and offer freedom from exogenous insulin. The most critical factor for a favorable metabolic outcome as a result of IAT is the transplanted islet cell mass, making islet isolation yield of outmost importance. This chapter discusses current islet cell isolation techniques utilized in processing of autologous pancreata in our center and others, with the goal of optimizing the isolation outcome.

Original languageEnglish (US)
Title of host publicationTransplantation, Bioengineering, and Regeneration of the Endocrine Pancreas
Subtitle of host publicationVolume 2
PublisherElsevier
Pages67-87
Number of pages21
ISBN (Electronic)9780128148310
ISBN (Print)9780128148327
DOIs
StatePublished - Jan 1 2019

Keywords

  • Allograft
  • Autograft
  • Chronic pancreatitis
  • Diabetes
  • Insulin independence
  • Islet autotransplant
  • Islet cells
  • Islet isolation
  • Near total pancreatectomy
  • Total pancreatectomy
  • Transplantation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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