Islet inflammation in plain sight

M. H. Abdulreda, Per-Olof Ynge Berggren

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

Although, diabetes is reaching pandemic proportions, the exact aetiology of either type 1 (T1D) or type 2 diabetes (T2D) remains to be determined. Mounting evidence, however, suggests that islet inflammation is a likely common denominator during early development of either type of the disease. In this review, we highlight some of the inflammatory mechanisms that appear to be shared between T1D and T2D, and we explore the utility of intravital imaging in the study of islet inflammation. Intravital imaging has emerged as an indispensable tool in biomedical research and a variety of in vivo imaging approaches have been developed to study pancreatic islet physiology and pathophysiology in the native environment in health and disease. However, given the scattered distribution of the islets of Langerhans within the 'sea' of the exocrine pancreas located deep within the body and the fact that the islets only constitute 1-2% of the total volume of pancreatic tissue, studying the pancreatic islet in situ has been challenging. Here, we focus on a new experimental approach that enables studying local islet inflammation with single-cell resolution in the relevant context of the in vivo environment non-invasively and longitudinally and, thereby improving our understanding of diabetes pathogenesis.

Original languageEnglish (US)
Pages (from-to)105-116
Number of pages12
JournalDiabetes, Obesity and Metabolism
Volume15
Issue numberS3
DOIs
StatePublished - Sep 2013

Keywords

  • Anterior chamber
  • ApoCIII
  • Diabetes
  • in vivo imaging
  • Inflammation
  • Insulin
  • Intraocular transplantation
  • Non-invasive
  • Pancreatic islet
  • T1D
  • T2D

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Fingerprint Dive into the research topics of 'Islet inflammation in plain sight'. Together they form a unique fingerprint.

  • Cite this