Abstract
Background: Islet of Langerhans' cell transplantation is a promising strategy for the treatment of type-1 diabetes mellitus. Results of this procedure have yet to match those of whole organ pancreas transplantation, but are rapidly improving, as witnessed by increasing rates of insulin independence and graft function (i.e., C-peptide production) after islet transplantation. Discussion: Identification of obstacles to the success of islet transplantation, such as primary nonfunction, immunosuppression-related metabolic workload, or recurrence of autoimmunity, will allow the development of new strategies tailored to overcome them. In particular, novel immunosuppressive protocols, with or without the aim of inducing tolerance, and immunoisolation devices are reaching the stage of clinical applicability. Finally, several strategies, such as utilization of porcine xenogeneic islets or genetically engineered β-cell lines, or in vitro expansion of cultured β-cells could theoretically expand indefinitely the pool of islet tissue for transplantation.
| Original language | English |
|---|---|
| Pages (from-to) | 373-378 |
| Number of pages | 6 |
| Journal | Langenbeck's Archives of Surgery |
| Volume | 385 |
| Issue number | 6 |
| State | Published - Nov 18 2000 |
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Keywords
- Diabetes mellitus
- Islet cell transplantation
ASJC Scopus subject areas
- Surgery
Cite this
Islet cell transplantation : The future? / Berney, Thierry; Ricordi, Camillo.
In: Langenbeck's Archives of Surgery, Vol. 385, No. 6, 18.11.2000, p. 373-378.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Islet cell transplantation
T2 - The future?
AU - Berney, Thierry
AU - Ricordi, Camillo
PY - 2000/11/18
Y1 - 2000/11/18
N2 - Background: Islet of Langerhans' cell transplantation is a promising strategy for the treatment of type-1 diabetes mellitus. Results of this procedure have yet to match those of whole organ pancreas transplantation, but are rapidly improving, as witnessed by increasing rates of insulin independence and graft function (i.e., C-peptide production) after islet transplantation. Discussion: Identification of obstacles to the success of islet transplantation, such as primary nonfunction, immunosuppression-related metabolic workload, or recurrence of autoimmunity, will allow the development of new strategies tailored to overcome them. In particular, novel immunosuppressive protocols, with or without the aim of inducing tolerance, and immunoisolation devices are reaching the stage of clinical applicability. Finally, several strategies, such as utilization of porcine xenogeneic islets or genetically engineered β-cell lines, or in vitro expansion of cultured β-cells could theoretically expand indefinitely the pool of islet tissue for transplantation.
AB - Background: Islet of Langerhans' cell transplantation is a promising strategy for the treatment of type-1 diabetes mellitus. Results of this procedure have yet to match those of whole organ pancreas transplantation, but are rapidly improving, as witnessed by increasing rates of insulin independence and graft function (i.e., C-peptide production) after islet transplantation. Discussion: Identification of obstacles to the success of islet transplantation, such as primary nonfunction, immunosuppression-related metabolic workload, or recurrence of autoimmunity, will allow the development of new strategies tailored to overcome them. In particular, novel immunosuppressive protocols, with or without the aim of inducing tolerance, and immunoisolation devices are reaching the stage of clinical applicability. Finally, several strategies, such as utilization of porcine xenogeneic islets or genetically engineered β-cell lines, or in vitro expansion of cultured β-cells could theoretically expand indefinitely the pool of islet tissue for transplantation.
KW - Diabetes mellitus
KW - Islet cell transplantation
UR - http://www.scopus.com/inward/record.url?scp=0033736567&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033736567&partnerID=8YFLogxK
M3 - Article
VL - 385
SP - 373
EP - 378
JO - Langenbeck's Archives of Surgery
JF - Langenbeck's Archives of Surgery
SN - 1435-2443
IS - 6
ER -