Islet cell transplantation

The future?

Thierry Berney, Camillo Ricordi

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background: Islet of Langerhans' cell transplantation is a promising strategy for the treatment of type-1 diabetes mellitus. Results of this procedure have yet to match those of whole organ pancreas transplantation, but are rapidly improving, as witnessed by increasing rates of insulin independence and graft function (i.e., C-peptide production) after islet transplantation. Discussion: Identification of obstacles to the success of islet transplantation, such as primary nonfunction, immunosuppression-related metabolic workload, or recurrence of autoimmunity, will allow the development of new strategies tailored to overcome them. In particular, novel immunosuppressive protocols, with or without the aim of inducing tolerance, and immunoisolation devices are reaching the stage of clinical applicability. Finally, several strategies, such as utilization of porcine xenogeneic islets or genetically engineered β-cell lines, or in vitro expansion of cultured β-cells could theoretically expand indefinitely the pool of islet tissue for transplantation.

Original languageEnglish
Pages (from-to)373-378
Number of pages6
JournalLangenbeck's Archives of Surgery
Volume385
Issue number6
StatePublished - Nov 18 2000

Fingerprint

Islets of Langerhans Transplantation
Cell Transplantation
Islets of Langerhans
Tissue Transplantation
Pancreas Transplantation
Langerhans Cells
C-Peptide
Organ Transplantation
Immunosuppressive Agents
Workload
Autoimmunity
Type 1 Diabetes Mellitus
Immunosuppression
Cultured Cells
Swine
Insulin
Transplants
Recurrence
Cell Line
Equipment and Supplies

Keywords

  • Diabetes mellitus
  • Islet cell transplantation

ASJC Scopus subject areas

  • Surgery

Cite this

Islet cell transplantation : The future? / Berney, Thierry; Ricordi, Camillo.

In: Langenbeck's Archives of Surgery, Vol. 385, No. 6, 18.11.2000, p. 373-378.

Research output: Contribution to journalArticle

Berney, Thierry ; Ricordi, Camillo. / Islet cell transplantation : The future?. In: Langenbeck's Archives of Surgery. 2000 ; Vol. 385, No. 6. pp. 373-378.
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