Islet cell allotransplantation in diabetic patients

Histologic findings in four adults simultaneously receiving kidney or liver transplants

C. E. Sever, A. J. Demetris, Y. Zeng, A. Tzakis, J. J. Fung, T. E. Starzl, Camillo Ricordi

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Refined methods of islet cell purification have led to unprecedented success of islet cell allotransplantation via portal vein infusion in diabetic patients, resulting in marked reduction of exogenous insulin requirements and recently even insulin independence. The authors report the histologic findings of islet cell allografts in the liver of four patients who had undergone combined kidney-islet or liver-islet transplantation. Islet cell clusters were detected in subcapsular location at the edge of portal triads. The early post-transplant period was characterized by patchy mixed portal infiltrates. Only minimal inflammation but decreased islet cell granulation was observed in one patient 6 months after transplantation. As histologic detection of transplanted islet cells becomes available, additional parameters for evaluation of graft survival might be defined by morphologic assessment.

Original languageEnglish
Pages (from-to)1255-1260
Number of pages6
JournalAmerican Journal of Pathology
Volume140
Issue number5
StatePublished - May 1 1992
Externally publishedYes

Fingerprint

Islets of Langerhans
Transplants
Kidney
Liver
Insulin
Islets of Langerhans Transplantation
Graft Survival
Portal Vein
Liver Transplantation
Allografts
Transplantation
Inflammation

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Islet cell allotransplantation in diabetic patients : Histologic findings in four adults simultaneously receiving kidney or liver transplants. / Sever, C. E.; Demetris, A. J.; Zeng, Y.; Tzakis, A.; Fung, J. J.; Starzl, T. E.; Ricordi, Camillo.

In: American Journal of Pathology, Vol. 140, No. 5, 01.05.1992, p. 1255-1260.

Research output: Contribution to journalArticle

Sever, C. E. ; Demetris, A. J. ; Zeng, Y. ; Tzakis, A. ; Fung, J. J. ; Starzl, T. E. ; Ricordi, Camillo. / Islet cell allotransplantation in diabetic patients : Histologic findings in four adults simultaneously receiving kidney or liver transplants. In: American Journal of Pathology. 1992 ; Vol. 140, No. 5. pp. 1255-1260.
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