Ischemic tolerance in stroke treatment

Nora Sandu, Jan Cornelius, Andreas Filis, Belachew Arasho, Miguel Perez-Pinzon, Bernhard Schaller

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

Although outcome after stroke treatment has significantly improved over the last 30 years, there has been no revolutionary breakthrough. Among different combined approaches, systemic thrombolysis in combination with neuroprotection became a favorite research target. Recent studies suggest that transient ischemic attacks may represent a clinical model of such ischemic tolerance; thus, a new focus on this research has emerged. In this review, we show the parallels between ischemia and neuroprotection and discuss the potential therapeutic options that may be opened by this new molecular knowledge.

Original languageEnglish (US)
Pages (from-to)1255-1261
Number of pages7
JournalExpert Review of Cardiovascular Therapy
Volume7
Issue number10
DOIs
StatePublished - Oct 2009

Keywords

  • Ischemic tolerance
  • Neuroprotection
  • Stroke
  • Transient ischemic attack
  • Treatment

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine

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    Sandu, N., Cornelius, J., Filis, A., Arasho, B., Perez-Pinzon, M., & Schaller, B. (2009). Ischemic tolerance in stroke treatment. Expert Review of Cardiovascular Therapy, 7(10), 1255-1261. https://doi.org/10.1586/erc.09.90