Ischemic preconditioning in the aging heart: From bench to bedside

Pasquale Abete, Francesco Cacciatore, Gianluca Testa, David Della Morte, Gianluigi Galizia, Domenico de Santis, Claudio Calabrese, Angelo Cioppa, Nicola Ferrara, Franco Rengo

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Coronary artery disease is the leading cause of death in industrialized countries for people older than 65 years of age. The reasons are still unclear. A reduction of endogenous mechanisms against ischemic insults has been proposed to explain this phenomenon. Cardiac ischemic preconditioning represents the most powerful endogenous protective mechanism against ischemia. Brief episodes of ischemia are able to protect the heart against a following more prolonged ischemic period. This protective mechanism seems to be reduced with aging both in experimental and clinical studies. Alterations of mediators release and/or intracellular pathways may be responsible for age-related ischemic preconditioning reduction. Opposite studies are questionable for the experimental model used, the timing of ischemic preconditioning, and the selection of elderly patients. Several pharmacological stimuli failed to mimic ischemic preconditioning in the aging heart but exercise training and caloric restriction separately, and more powerfully taken together, are able to completely preserve and/or restore the age-related reduction of ischemic preconditioning.

Original languageEnglish
Pages (from-to)153-162
Number of pages10
JournalAgeing Research Reviews
Volume9
Issue number2
DOIs
StatePublished - Apr 1 2010

Fingerprint

Ischemic Preconditioning
Aging of materials
Ischemia
Caloric Restriction
Developed Countries
Patient Selection
Coronary Artery Disease
Cause of Death
Theoretical Models
Pharmacology
Exercise

Keywords

  • Coronary artery disease
  • Ischemic preconditioning
  • Lifestyles

ASJC Scopus subject areas

  • Aging
  • Biochemistry
  • Biotechnology
  • Molecular Biology
  • Neurology

Cite this

Abete, P., Cacciatore, F., Testa, G., Della Morte, D., Galizia, G., de Santis, D., ... Rengo, F. (2010). Ischemic preconditioning in the aging heart: From bench to bedside. Ageing Research Reviews, 9(2), 153-162. https://doi.org/10.1016/j.arr.2009.07.001

Ischemic preconditioning in the aging heart : From bench to bedside. / Abete, Pasquale; Cacciatore, Francesco; Testa, Gianluca; Della Morte, David; Galizia, Gianluigi; de Santis, Domenico; Calabrese, Claudio; Cioppa, Angelo; Ferrara, Nicola; Rengo, Franco.

In: Ageing Research Reviews, Vol. 9, No. 2, 01.04.2010, p. 153-162.

Research output: Contribution to journalArticle

Abete, P, Cacciatore, F, Testa, G, Della Morte, D, Galizia, G, de Santis, D, Calabrese, C, Cioppa, A, Ferrara, N & Rengo, F 2010, 'Ischemic preconditioning in the aging heart: From bench to bedside', Ageing Research Reviews, vol. 9, no. 2, pp. 153-162. https://doi.org/10.1016/j.arr.2009.07.001
Abete, Pasquale ; Cacciatore, Francesco ; Testa, Gianluca ; Della Morte, David ; Galizia, Gianluigi ; de Santis, Domenico ; Calabrese, Claudio ; Cioppa, Angelo ; Ferrara, Nicola ; Rengo, Franco. / Ischemic preconditioning in the aging heart : From bench to bedside. In: Ageing Research Reviews. 2010 ; Vol. 9, No. 2. pp. 153-162.
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