Ischemic neuronal damage after acute subdural hematoma in the rat: Effects of pretreatment with a glutamate antagonist

M. H. Chen, Ross Bullock, D. I. Graham, J. D. Miller, J. McCulloch

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

The ability of a competitive N-methyl-D-aspartate (NMDA) receptor antagonist (D-CPP-ene) to reduce irreversible brain damage has been examined in a rodent model of acute subdural hematoma. Acute subdural hematoma was produced by the slow injection of 400 μl homologous blood into the subdural space overlying the parietal cortex in halothane-anesthetized rats. Brain damage was assessed histologically in sections at multiple coronal planes in animals sacrificed 4 hours after induction of the subdural hematoma. Pretreatment with D-CPP-ene (15 mg/kg) significantly reduced the volume of ischemic brain damage produced by the subdural hematoma from 62 ± 8cu mm (mean ± standard error of the mean) in vehicle-treated control rats to 29 ± 7 cu mm in drug-treated animals. These data demonstrate the anti-ischemic efficacy of NMDA antagonists in an animal model of intracranial hemorrhage in which intracranial pressure is elevated, and suggest that excitotoxic mechanisms (which are susceptible to antagonism by D-CPP-ene) may play a role in the ischemic brain damage which is observed in patients who die after acute subdural hematoma.

Original languageEnglish
Pages (from-to)944-950
Number of pages7
JournalJournal of Neurosurgery
Volume74
Issue number6
StatePublished - Jan 1 1991
Externally publishedYes

Fingerprint

Hematoma, Subdural, Acute
Excitatory Amino Acid Antagonists
Subdural Hematoma
Brain
Subdural Space
Parietal Lobe
Intracranial Hypertension
Intracranial Hemorrhages
Halothane
N-Methylaspartate
N-Methyl-D-Aspartate Receptors
Rodentia
Animal Models
Injections
Pharmaceutical Preparations
SDZ EAA 494

Keywords

  • glutamate antagonist
  • ischemic brain damage
  • neuronal damage
  • rat
  • subdural hematoma

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Chen, M. H., Bullock, R., Graham, D. I., Miller, J. D., & McCulloch, J. (1991). Ischemic neuronal damage after acute subdural hematoma in the rat: Effects of pretreatment with a glutamate antagonist. Journal of Neurosurgery, 74(6), 944-950.

Ischemic neuronal damage after acute subdural hematoma in the rat : Effects of pretreatment with a glutamate antagonist. / Chen, M. H.; Bullock, Ross; Graham, D. I.; Miller, J. D.; McCulloch, J.

In: Journal of Neurosurgery, Vol. 74, No. 6, 01.01.1991, p. 944-950.

Research output: Contribution to journalArticle

Chen, MH, Bullock, R, Graham, DI, Miller, JD & McCulloch, J 1991, 'Ischemic neuronal damage after acute subdural hematoma in the rat: Effects of pretreatment with a glutamate antagonist', Journal of Neurosurgery, vol. 74, no. 6, pp. 944-950.
Chen, M. H. ; Bullock, Ross ; Graham, D. I. ; Miller, J. D. ; McCulloch, J. / Ischemic neuronal damage after acute subdural hematoma in the rat : Effects of pretreatment with a glutamate antagonist. In: Journal of Neurosurgery. 1991 ; Vol. 74, No. 6. pp. 944-950.
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