Ischemic neuronal damage after acute subdural hematoma in the rat: Effects of pretreatment with a glutamate antagonist

M. H. Chen, R. Bullock, D. I. Graham, J. D. Miller, J. McCulloch

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81 Scopus citations


The ability of a competitive N-methyl-D-aspartate (NMDA) receptor antagonist (D-CPP-ene) to reduce irreversible brain damage has been examined in a rodent model of acute subdural hematoma. Acute subdural hematoma was produced by the slow injection of 400 μl homologous blood into the subdural space overlying the parietal cortex in halothane-anesthetized rats. Brain damage was assessed histologically in sections at multiple coronal planes in animals sacrificed 4 hours after induction of the subdural hematoma. Pretreatment with D-CPP-ene (15 mg/kg) significantly reduced the volume of ischemic brain damage produced by the subdural hematoma from 62 ± 8cu mm (mean ± standard error of the mean) in vehicle-treated control rats to 29 ± 7 cu mm in drug-treated animals. These data demonstrate the anti-ischemic efficacy of NMDA antagonists in an animal model of intracranial hemorrhage in which intracranial pressure is elevated, and suggest that excitotoxic mechanisms (which are susceptible to antagonism by D-CPP-ene) may play a role in the ischemic brain damage which is observed in patients who die after acute subdural hematoma.

Original languageEnglish (US)
Pages (from-to)944-950
Number of pages7
JournalJournal of neurosurgery
Issue number6
StatePublished - Jan 1 1991



  • glutamate antagonist
  • ischemic brain damage
  • neuronal damage
  • rat
  • subdural hematoma

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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