Ischemic brain damage in a model of acute subdural hematoma

J. D. Miller, R. Bullock, D. I. Graham, Min-Hsiung-Chen, G. M. Teasdale

Research output: Contribution to journalArticle

129 Scopus citations

Abstract

Ischemic brain damage is the most important neuropathological finding in humans who die after acute subdural hematoma; however, its causes are poorly understood. We have produced acute subdural hematoma in the rat by injecting 400 μl of autologous blood (~20% of intracranial volume) into the subdural space. Extensive areas of ischemic damage, involving 14 to 16% of the volume of the hemisphere, developed in this model at 4 and 24 hours after the lesion. The hematomas were associated with a brief peak in intracranial pressure (51 mm Hg), which remained at three times normal levels (14 mm Hg) for 3 hours. In this model, therefore, ischemic damage appears to be due to the local effects of blood overlying the cortex at 4 hours after the ictus, rather than to globally raised intracranial pressure. The implications for the pathophysiology of acute subdural hematomas in humans are discussed.

Original languageEnglish (US)
Pages (from-to)433-439
Number of pages7
JournalNeurosurgery
Volume27
Issue number3
DOIs
StatePublished - Jan 1 1990

Keywords

  • acute subdural hematoma
  • intracranial pressure
  • ischemic brain damage

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

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    Miller, J. D., Bullock, R., Graham, D. I., Min-Hsiung-Chen, & Teasdale, G. M. (1990). Ischemic brain damage in a model of acute subdural hematoma. Neurosurgery, 27(3), 433-439. https://doi.org/10.1227/00006123-199009000-00016