Is there a Role for Surgery with Adequate Nodal Evaluation Alone in Gastric Adenocarcinoma?

Vikas Dudeja, Elizabeth B. Habermann, Anasooya Abraham, Wei Zhong, Helen M. Parsons, Jennifer F. Tseng, Waddah B. Al-Refaie

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Introduction: The extent of lymphadenectomy and protocol design in gastric cancer trials limits interpretation of survival benefit of adjuvant therapy after surgery with adequate lymphadenectomy. We examined the impact of surgery with adequate nodal evaluation alone on gastric cancer survival. Methods: Using 2001-2008 California Cancer Registry, we identified 2,229 patients who underwent gastrectomy with adequate nodal evaluation (≥15 lymph nodes) for American Joint Committee on Cancer stage I-IV M0 gastric adenocarcinoma. Cox proportional hazard analyses were used to evaluate the impact of surgery alone on survival. Results: Nearly 70% of our cohort had T1/2 tumors and 29% had N0 disease. Forty-nine percent of the cohort underwent surgery alone. These patients were more likely to be older, Medicare-insured, with T1 and N0 disease. On unadjusted analyses, persons who underwent surgery alone for stage I or N0 disease experienced 1- and 3-year overall and cancer-specific survival comparable to those who received adjuvant therapy. On multivariate analyses for stage I or N0 disease, surgery alone predicted superior survival outcomes than when combined with adjuvant therapies. Conclusion: Surgery alone with adequate nodal evaluation may have a role in low-risk gastric cancer. To corroborate these findings, surgery with adequate lymphadenectomy alone (as treatment arm) deserves consideration in the design of gastric cancer trials to provide effective yet resource-conserving, rather than maximally tolerated, treatments.

Original languageEnglish (US)
Pages (from-to)238-247
Number of pages10
JournalJournal of Gastrointestinal Surgery
Volume16
Issue number2
DOIs
StatePublished - Feb 1 2012
Externally publishedYes

Fingerprint

Stomach
Adenocarcinoma
Stomach Neoplasms
Lymph Node Excision
Survival
Neoplasms
Therapeutics
Gastrectomy
Medicare
Registries
Multivariate Analysis
Lymph Nodes

Keywords

  • Adjuvant therapy
  • California Cancer Registry
  • Gastric cancer
  • Surgery with adequate lymphadenectomy alone
  • Survival

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology

Cite this

Dudeja, V., Habermann, E. B., Abraham, A., Zhong, W., Parsons, H. M., Tseng, J. F., & Al-Refaie, W. B. (2012). Is there a Role for Surgery with Adequate Nodal Evaluation Alone in Gastric Adenocarcinoma? Journal of Gastrointestinal Surgery, 16(2), 238-247. https://doi.org/10.1007/s11605-011-1756-7

Is there a Role for Surgery with Adequate Nodal Evaluation Alone in Gastric Adenocarcinoma? / Dudeja, Vikas; Habermann, Elizabeth B.; Abraham, Anasooya; Zhong, Wei; Parsons, Helen M.; Tseng, Jennifer F.; Al-Refaie, Waddah B.

In: Journal of Gastrointestinal Surgery, Vol. 16, No. 2, 01.02.2012, p. 238-247.

Research output: Contribution to journalArticle

Dudeja, V, Habermann, EB, Abraham, A, Zhong, W, Parsons, HM, Tseng, JF & Al-Refaie, WB 2012, 'Is there a Role for Surgery with Adequate Nodal Evaluation Alone in Gastric Adenocarcinoma?', Journal of Gastrointestinal Surgery, vol. 16, no. 2, pp. 238-247. https://doi.org/10.1007/s11605-011-1756-7
Dudeja, Vikas ; Habermann, Elizabeth B. ; Abraham, Anasooya ; Zhong, Wei ; Parsons, Helen M. ; Tseng, Jennifer F. ; Al-Refaie, Waddah B. / Is there a Role for Surgery with Adequate Nodal Evaluation Alone in Gastric Adenocarcinoma?. In: Journal of Gastrointestinal Surgery. 2012 ; Vol. 16, No. 2. pp. 238-247.
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