TY - JOUR
T1 - Is there a place for genetics in the management of PONV?
AU - Candiotti, Keith
AU - Shrestha, Chandrama
AU - Silva Ceschim, Mariana Rubini
N1 - Publisher Copyright:
© 2020 Elsevier Ltd
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/12
Y1 - 2020/12
N2 - Antiemetic prophylaxis for postoperative nausea and vomiting (PONV) – a frequent complication in the postoperative period – is routinely given to high-risk patients. However, standard PONV risk models do not account for genetic factors, which have been shown to have a significant influence on PONV incidence and drug response. In this review, we describe the polymorphisms of various genes (serotonin, dopamine, cholinergic, etc.) and how pharmacogenomics is involved in the pathophysiology of PONV. This review also addresses how genetics is involved in today's clinical practice related to PONV and how it will change in the upcoming years as personalized medicine advances.
AB - Antiemetic prophylaxis for postoperative nausea and vomiting (PONV) – a frequent complication in the postoperative period – is routinely given to high-risk patients. However, standard PONV risk models do not account for genetic factors, which have been shown to have a significant influence on PONV incidence and drug response. In this review, we describe the polymorphisms of various genes (serotonin, dopamine, cholinergic, etc.) and how pharmacogenomics is involved in the pathophysiology of PONV. This review also addresses how genetics is involved in today's clinical practice related to PONV and how it will change in the upcoming years as personalized medicine advances.
KW - antiemetics
KW - genetics
KW - pharmacogenetics
KW - pharmacogenomic testing
KW - postoperative nausea and vomiting
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U2 - 10.1016/j.bpa.2020.05.002
DO - 10.1016/j.bpa.2020.05.002
M3 - Review article
C2 - 33288121
AN - SCOPUS:85085976353
VL - 34
SP - 713
EP - 720
JO - Best Practice and Research: Clinical Anaesthesiology
JF - Best Practice and Research: Clinical Anaesthesiology
SN - 1521-6896
IS - 4
ER -