Is there a place for genetics in the management of PONV?

Keith Candiotti; Chandrama Shrestha; Mariana Rubini Silva Ceschim

doi:10.1016/j.bpa.2020.05.002

Is there a place for genetics in the management of PONV?

Keith Candiotti, Chandrama Shrestha, Mariana Rubini Silva Ceschim

Anesthesiology

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Antiemetic prophylaxis for postoperative nausea and vomiting (PONV) – a frequent complication in the postoperative period – is routinely given to high-risk patients. However, standard PONV risk models do not account for genetic factors, which have been shown to have a significant influence on PONV incidence and drug response. In this review, we describe the polymorphisms of various genes (serotonin, dopamine, cholinergic, etc.) and how pharmacogenomics is involved in the pathophysiology of PONV. This review also addresses how genetics is involved in today's clinical practice related to PONV and how it will change in the upcoming years as personalized medicine advances.

Original language	English (US)
Pages (from-to)	713-720
Number of pages	8
Journal	Best Practice and Research: Clinical Anaesthesiology
Volume	34
Issue number	4
DOIs	https://doi.org/10.1016/j.bpa.2020.05.002
State	Published - Dec 2020

Keywords

antiemetics
genetics
pharmacogenetics
pharmacogenomic testing
postoperative nausea and vomiting

ASJC Scopus subject areas

Anesthesiology and Pain Medicine

Access to Document

10.1016/j.bpa.2020.05.002

Cite this

@article{163cc829316c4632b6bd8613a80cd182,

title = "Is there a place for genetics in the management of PONV?",

abstract = "Antiemetic prophylaxis for postoperative nausea and vomiting (PONV) – a frequent complication in the postoperative period – is routinely given to high-risk patients. However, standard PONV risk models do not account for genetic factors, which have been shown to have a significant influence on PONV incidence and drug response. In this review, we describe the polymorphisms of various genes (serotonin, dopamine, cholinergic, etc.) and how pharmacogenomics is involved in the pathophysiology of PONV. This review also addresses how genetics is involved in today's clinical practice related to PONV and how it will change in the upcoming years as personalized medicine advances.",

keywords = "antiemetics, genetics, pharmacogenetics, pharmacogenomic testing, postoperative nausea and vomiting",

author = "Keith Candiotti and Chandrama Shrestha and {Silva Ceschim}, {Mariana Rubini}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",

year = "2020",

month = dec,

doi = "10.1016/j.bpa.2020.05.002",

language = "English (US)",

volume = "34",

pages = "713--720",

journal = "Best Practice and Research: Clinical Anaesthesiology",