Is there a place for genetics in the management of PONV?

Keith Candiotti, Chandrama Shrestha, Mariana Rubini Silva Ceschim

Research output: Contribution to journal › Review article › peer-review

Abstract

Antiemetic prophylaxis for postoperative nausea and vomiting (PONV) – a frequent complication in the postoperative period – is routinely given to high-risk patients. However, standard PONV risk models do not account for genetic factors, which have been shown to have a significant influence on PONV incidence and drug response. In this review, we describe the polymorphisms of various genes (serotonin, dopamine, cholinergic, etc.) and how pharmacogenomics is involved in the pathophysiology of PONV. This review also addresses how genetics is involved in today's clinical practice related to PONV and how it will change in the upcoming years as personalized medicine advances.

Original languageEnglish (US)
Pages (from-to)713-720
Number of pages8
JournalBest Practice and Research: Clinical Anaesthesiology
Volume34
Issue number4
DOIs
StatePublished - Dec 2020

Keywords

  • antiemetics
  • genetics
  • pharmacogenetics
  • pharmacogenomic testing
  • postoperative nausea and vomiting

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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