Is there a 'gut-brain-skin axis'?

Petra Arck, Bori Handjiski, Evelin Hagen, Maike Pincus, Christian Bruenahl, John Bienenstock, Ralf Paus

Research output: Contribution to journalComment/debate

51 Citations (Scopus)

Abstract

Emerging evidence arising from interdisciplinary research supports the occurrence of communication axes between organs, such as the brain-gut or brain-skin axis. The latter is employed in response to stress challenge, along which neurogenic skin inflammation and hair growth inhibition is mediated. We now show that ingestion of a Lactobacillus strain in mice dampens stress-induced neurogenic skin inflammation and the hair growth inhibition. In conclusion, we are introducing a hypothesis, encouraged by our pilot observations and resting upon published prior evidence from the literature, which amalgamates previously proposed partial concepts into a new, unifying model, i.e. the gut-brain-skin axis. This concept suggests that modulation of the microbiome by deployment of probiotics can not only greatly reduce stress-induced neurogenic skin inflammation but even affect a very complex cutaneous phenomenon of (mini-) organ transformation, i.e. hair follicle cycling. These observations raise the intriguing prospect that feeding of just the right kind of bacteria can exert profound beneficial effects on skin homoeostasis, skin inflammation, hair growth and peripheral tissue responses to perceived stress.

Original languageEnglish (US)
Pages (from-to)401-405
Number of pages5
JournalExperimental Dermatology
Volume19
Issue number5
DOIs
StatePublished - May 1 2010
Externally publishedYes

Fingerprint

Brain
Skin
Neurogenic Inflammation
Hair
Growth
Hair Follicle
Microbiota
Probiotics
Lactobacillus
Bacteria
Modulation
Homeostasis
Tissue
Eating
Communication
Inflammation
Research

Keywords

  • Allostasis
  • Hair follicle
  • Immunity
  • Lactobacillus
  • Stress

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology

Cite this

Arck, P., Handjiski, B., Hagen, E., Pincus, M., Bruenahl, C., Bienenstock, J., & Paus, R. (2010). Is there a 'gut-brain-skin axis'? Experimental Dermatology, 19(5), 401-405. https://doi.org/10.1111/j.1600-0625.2009.01060.x

Is there a 'gut-brain-skin axis'? / Arck, Petra; Handjiski, Bori; Hagen, Evelin; Pincus, Maike; Bruenahl, Christian; Bienenstock, John; Paus, Ralf.

In: Experimental Dermatology, Vol. 19, No. 5, 01.05.2010, p. 401-405.

Research output: Contribution to journalComment/debate

Arck, P, Handjiski, B, Hagen, E, Pincus, M, Bruenahl, C, Bienenstock, J & Paus, R 2010, 'Is there a 'gut-brain-skin axis'?', Experimental Dermatology, vol. 19, no. 5, pp. 401-405. https://doi.org/10.1111/j.1600-0625.2009.01060.x
Arck P, Handjiski B, Hagen E, Pincus M, Bruenahl C, Bienenstock J et al. Is there a 'gut-brain-skin axis'? Experimental Dermatology. 2010 May 1;19(5):401-405. https://doi.org/10.1111/j.1600-0625.2009.01060.x
Arck, Petra ; Handjiski, Bori ; Hagen, Evelin ; Pincus, Maike ; Bruenahl, Christian ; Bienenstock, John ; Paus, Ralf. / Is there a 'gut-brain-skin axis'?. In: Experimental Dermatology. 2010 ; Vol. 19, No. 5. pp. 401-405.
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