Is the incidence of uretero-intestinal anastomotic stricture increased in patients undergoing radical cystectomy with previous pelvic radiation?

Devendar Katkoori, Srinivas Samavedi, Kishore Thekke Adiyat, Mark S. Soloway, Murugesan Manoharan

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Study Type - Therapy (case series) Level of Evidence 4 Objective: To present our long-term experience comparing uretero-intestinal anastomotic (UIA) stricture rates after radical cystectomy (RC) in patients with and without previous pelvic radiotherapy (pRT), as the risk of stricture is thought to be higher in patients undergoing RC and urinary diversion (UD) with a history of pRT. Patients and methods: We retrospectively analysed patients who had RC and UD between 1992 and 2008 by one surgical team. Patients were divided into two groups, those with (group 1) and with no (group 2) previous pRT. Relevant clinical and pathological data were entered into a database. Patients who were symptomatic and required intervention for a UIA stricture were analysed; patients with malignant strictures were excluded. Results: In all, 526 patients had RC by one surgical team during the study period; 65 had pRT before RC, 37 for prostate cancer, 23 for bladder cancer and the rest for other pelvic malignancies. All the patients in group 1 had an ileal conduit (IC) diversion. There were 250 IC and 211 neobladder diversions in group 2. There were 130 (12%) UIAs in group 1, vs 922 (88%) in group 2. There was no statistically significant difference between the groups in demographic profile and follow-up. The overall stricture rate for UIA was 1.3%; there were two (1.5%) UIA strictures in group 1 vs 12 (1.3%) in group 2. The mean (median, range) time to onset of the stricture was 10 (6, 2-39) months. There was no statistically significant difference in stricture rate between the groups (P > 0.05). Conclusion:S In patients undergoing RC with UD there was no significant difference in UIA stricture rates between those with and without previous pRT.

Original languageEnglish
Pages (from-to)795-798
Number of pages4
JournalBJU International
Volume105
Issue number6
DOIs
StatePublished - Mar 1 2010

Fingerprint

Cystectomy
Pathologic Constriction
Radiation
Urinary Diversion
Incidence
Radiotherapy
Urinary Bladder Neoplasms
Prostatic Neoplasms
Demography
Databases

Keywords

  • Bladder cancer
  • Pelvic radiation
  • Radical cystectomy
  • Stricture
  • Uretero-intestinal anastomosis

ASJC Scopus subject areas

  • Urology

Cite this

Is the incidence of uretero-intestinal anastomotic stricture increased in patients undergoing radical cystectomy with previous pelvic radiation? / Katkoori, Devendar; Samavedi, Srinivas; Adiyat, Kishore Thekke; Soloway, Mark S.; Manoharan, Murugesan.

In: BJU International, Vol. 105, No. 6, 01.03.2010, p. 795-798.

Research output: Contribution to journalArticle

Katkoori, Devendar ; Samavedi, Srinivas ; Adiyat, Kishore Thekke ; Soloway, Mark S. ; Manoharan, Murugesan. / Is the incidence of uretero-intestinal anastomotic stricture increased in patients undergoing radical cystectomy with previous pelvic radiation?. In: BJU International. 2010 ; Vol. 105, No. 6. pp. 795-798.
@article{d2fc477a3dfc416c8f17ac856f9eb245,
title = "Is the incidence of uretero-intestinal anastomotic stricture increased in patients undergoing radical cystectomy with previous pelvic radiation?",
abstract = "Study Type - Therapy (case series) Level of Evidence 4 Objective: To present our long-term experience comparing uretero-intestinal anastomotic (UIA) stricture rates after radical cystectomy (RC) in patients with and without previous pelvic radiotherapy (pRT), as the risk of stricture is thought to be higher in patients undergoing RC and urinary diversion (UD) with a history of pRT. Patients and methods: We retrospectively analysed patients who had RC and UD between 1992 and 2008 by one surgical team. Patients were divided into two groups, those with (group 1) and with no (group 2) previous pRT. Relevant clinical and pathological data were entered into a database. Patients who were symptomatic and required intervention for a UIA stricture were analysed; patients with malignant strictures were excluded. Results: In all, 526 patients had RC by one surgical team during the study period; 65 had pRT before RC, 37 for prostate cancer, 23 for bladder cancer and the rest for other pelvic malignancies. All the patients in group 1 had an ileal conduit (IC) diversion. There were 250 IC and 211 neobladder diversions in group 2. There were 130 (12{\%}) UIAs in group 1, vs 922 (88{\%}) in group 2. There was no statistically significant difference between the groups in demographic profile and follow-up. The overall stricture rate for UIA was 1.3{\%}; there were two (1.5{\%}) UIA strictures in group 1 vs 12 (1.3{\%}) in group 2. The mean (median, range) time to onset of the stricture was 10 (6, 2-39) months. There was no statistically significant difference in stricture rate between the groups (P > 0.05). Conclusion:S In patients undergoing RC with UD there was no significant difference in UIA stricture rates between those with and without previous pRT.",
keywords = "Bladder cancer, Pelvic radiation, Radical cystectomy, Stricture, Uretero-intestinal anastomosis",
author = "Devendar Katkoori and Srinivas Samavedi and Adiyat, {Kishore Thekke} and Soloway, {Mark S.} and Murugesan Manoharan",
year = "2010",
month = "3",
day = "1",
doi = "10.1111/j.1464-410X.2009.08835.x",
language = "English",
volume = "105",
pages = "795--798",
journal = "BJU International",
issn = "1464-4096",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Is the incidence of uretero-intestinal anastomotic stricture increased in patients undergoing radical cystectomy with previous pelvic radiation?

AU - Katkoori, Devendar

AU - Samavedi, Srinivas

AU - Adiyat, Kishore Thekke

AU - Soloway, Mark S.

AU - Manoharan, Murugesan

PY - 2010/3/1

Y1 - 2010/3/1

N2 - Study Type - Therapy (case series) Level of Evidence 4 Objective: To present our long-term experience comparing uretero-intestinal anastomotic (UIA) stricture rates after radical cystectomy (RC) in patients with and without previous pelvic radiotherapy (pRT), as the risk of stricture is thought to be higher in patients undergoing RC and urinary diversion (UD) with a history of pRT. Patients and methods: We retrospectively analysed patients who had RC and UD between 1992 and 2008 by one surgical team. Patients were divided into two groups, those with (group 1) and with no (group 2) previous pRT. Relevant clinical and pathological data were entered into a database. Patients who were symptomatic and required intervention for a UIA stricture were analysed; patients with malignant strictures were excluded. Results: In all, 526 patients had RC by one surgical team during the study period; 65 had pRT before RC, 37 for prostate cancer, 23 for bladder cancer and the rest for other pelvic malignancies. All the patients in group 1 had an ileal conduit (IC) diversion. There were 250 IC and 211 neobladder diversions in group 2. There were 130 (12%) UIAs in group 1, vs 922 (88%) in group 2. There was no statistically significant difference between the groups in demographic profile and follow-up. The overall stricture rate for UIA was 1.3%; there were two (1.5%) UIA strictures in group 1 vs 12 (1.3%) in group 2. The mean (median, range) time to onset of the stricture was 10 (6, 2-39) months. There was no statistically significant difference in stricture rate between the groups (P > 0.05). Conclusion:S In patients undergoing RC with UD there was no significant difference in UIA stricture rates between those with and without previous pRT.

AB - Study Type - Therapy (case series) Level of Evidence 4 Objective: To present our long-term experience comparing uretero-intestinal anastomotic (UIA) stricture rates after radical cystectomy (RC) in patients with and without previous pelvic radiotherapy (pRT), as the risk of stricture is thought to be higher in patients undergoing RC and urinary diversion (UD) with a history of pRT. Patients and methods: We retrospectively analysed patients who had RC and UD between 1992 and 2008 by one surgical team. Patients were divided into two groups, those with (group 1) and with no (group 2) previous pRT. Relevant clinical and pathological data were entered into a database. Patients who were symptomatic and required intervention for a UIA stricture were analysed; patients with malignant strictures were excluded. Results: In all, 526 patients had RC by one surgical team during the study period; 65 had pRT before RC, 37 for prostate cancer, 23 for bladder cancer and the rest for other pelvic malignancies. All the patients in group 1 had an ileal conduit (IC) diversion. There were 250 IC and 211 neobladder diversions in group 2. There were 130 (12%) UIAs in group 1, vs 922 (88%) in group 2. There was no statistically significant difference between the groups in demographic profile and follow-up. The overall stricture rate for UIA was 1.3%; there were two (1.5%) UIA strictures in group 1 vs 12 (1.3%) in group 2. The mean (median, range) time to onset of the stricture was 10 (6, 2-39) months. There was no statistically significant difference in stricture rate between the groups (P > 0.05). Conclusion:S In patients undergoing RC with UD there was no significant difference in UIA stricture rates between those with and without previous pRT.

KW - Bladder cancer

KW - Pelvic radiation

KW - Radical cystectomy

KW - Stricture

KW - Uretero-intestinal anastomosis

UR - http://www.scopus.com/inward/record.url?scp=77649259301&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77649259301&partnerID=8YFLogxK

U2 - 10.1111/j.1464-410X.2009.08835.x

DO - 10.1111/j.1464-410X.2009.08835.x

M3 - Article

C2 - 19725823

AN - SCOPUS:77649259301

VL - 105

SP - 795

EP - 798

JO - BJU International

JF - BJU International

SN - 1464-4096

IS - 6

ER -