Is the eccrine gland an integral, functionally important component of the human scalp pilosebaceous unit?

Enrique Poblet, Francisco Jiménez-Acosta, Jonathan A. Hardman, Eduardo Escario, Ralf Paus

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The pilosebaceous unit (PSU) and the eccrine sweat gland (ESG) are classically described as completely independent skin appendages. However, careful inspection of scalp follicular units reveals that the secretory segment of the ESG spatially approximates the hair follicle in a position below the sebaceous gland and the insertion of the arrector pili muscle. Therefore, we propose here that, contrary to conventional wisdom, the PSU and the ESG should not be viewed in isolation, and may form instead, along with the arrector pili muscle and the apocrine gland (where present),one functional unit. For this, we suggest the more inclusive term of 'Hair Cluster' (HC). If confirmed, e.g. by 3D imaging techniques, the novel concept of a functional HC, whose individual components may communicate via secreted molecules and may share selected progenitor cell populations for HC repair/regeneration, has major physiological and pathological implications, which are briefly discussed.

Original languageEnglish (US)
Pages (from-to)149-150
Number of pages2
JournalExperimental Dermatology
Volume25
Issue number2
DOIs
StatePublished - Feb 1 2016
Externally publishedYes

Fingerprint

Eccrine Glands
Sweat Glands
Scalp
Hair
Muscle
Apocrine Glands
Sebaceous Glands
Muscles
Skin
Repair
Hair Follicle
Inspection
Cells
Imaging techniques
Molecules
Regeneration
Stem Cells
Population

Keywords

  • Eccrine sweat gland
  • Hair follicle

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology

Cite this

Is the eccrine gland an integral, functionally important component of the human scalp pilosebaceous unit? / Poblet, Enrique; Jiménez-Acosta, Francisco; Hardman, Jonathan A.; Escario, Eduardo; Paus, Ralf.

In: Experimental Dermatology, Vol. 25, No. 2, 01.02.2016, p. 149-150.

Research output: Contribution to journalArticle

Poblet, Enrique ; Jiménez-Acosta, Francisco ; Hardman, Jonathan A. ; Escario, Eduardo ; Paus, Ralf. / Is the eccrine gland an integral, functionally important component of the human scalp pilosebaceous unit?. In: Experimental Dermatology. 2016 ; Vol. 25, No. 2. pp. 149-150.
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