Abstract
The pilosebaceous unit (PSU) and the eccrine sweat gland (ESG) are classically described as completely independent skin appendages. However, careful inspection of scalp follicular units reveals that the secretory segment of the ESG spatially approximates the hair follicle in a position below the sebaceous gland and the insertion of the arrector pili muscle. Therefore, we propose here that, contrary to conventional wisdom, the PSU and the ESG should not be viewed in isolation, and may form instead, along with the arrector pili muscle and the apocrine gland (where present),one functional unit. For this, we suggest the more inclusive term of 'Hair Cluster' (HC). If confirmed, e.g. by 3D imaging techniques, the novel concept of a functional HC, whose individual components may communicate via secreted molecules and may share selected progenitor cell populations for HC repair/regeneration, has major physiological and pathological implications, which are briefly discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 149-150 |
| Number of pages | 2 |
| Journal | Experimental Dermatology |
| Volume | 25 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1 2016 |
| Externally published | Yes |
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Keywords
- Eccrine sweat gland
- Hair follicle
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Dermatology
Cite this
Is the eccrine gland an integral, functionally important component of the human scalp pilosebaceous unit? / Poblet, Enrique; Jiménez-Acosta, Francisco; Hardman, Jonathan A.; Escario, Eduardo; Paus, Ralf.
In: Experimental Dermatology, Vol. 25, No. 2, 01.02.2016, p. 149-150.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Is the eccrine gland an integral, functionally important component of the human scalp pilosebaceous unit?
AU - Poblet, Enrique
AU - Jiménez-Acosta, Francisco
AU - Hardman, Jonathan A.
AU - Escario, Eduardo
AU - Paus, Ralf
PY - 2016/2/1
Y1 - 2016/2/1
N2 - The pilosebaceous unit (PSU) and the eccrine sweat gland (ESG) are classically described as completely independent skin appendages. However, careful inspection of scalp follicular units reveals that the secretory segment of the ESG spatially approximates the hair follicle in a position below the sebaceous gland and the insertion of the arrector pili muscle. Therefore, we propose here that, contrary to conventional wisdom, the PSU and the ESG should not be viewed in isolation, and may form instead, along with the arrector pili muscle and the apocrine gland (where present),one functional unit. For this, we suggest the more inclusive term of 'Hair Cluster' (HC). If confirmed, e.g. by 3D imaging techniques, the novel concept of a functional HC, whose individual components may communicate via secreted molecules and may share selected progenitor cell populations for HC repair/regeneration, has major physiological and pathological implications, which are briefly discussed.
AB - The pilosebaceous unit (PSU) and the eccrine sweat gland (ESG) are classically described as completely independent skin appendages. However, careful inspection of scalp follicular units reveals that the secretory segment of the ESG spatially approximates the hair follicle in a position below the sebaceous gland and the insertion of the arrector pili muscle. Therefore, we propose here that, contrary to conventional wisdom, the PSU and the ESG should not be viewed in isolation, and may form instead, along with the arrector pili muscle and the apocrine gland (where present),one functional unit. For this, we suggest the more inclusive term of 'Hair Cluster' (HC). If confirmed, e.g. by 3D imaging techniques, the novel concept of a functional HC, whose individual components may communicate via secreted molecules and may share selected progenitor cell populations for HC repair/regeneration, has major physiological and pathological implications, which are briefly discussed.
KW - Eccrine sweat gland
KW - Hair follicle
UR - http://www.scopus.com/inward/record.url?scp=84969322071&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84969322071&partnerID=8YFLogxK
U2 - 10.1111/exd.12889
DO - 10.1111/exd.12889
M3 - Article
C2 - 26513332
AN - SCOPUS:84969322071
VL - 25
SP - 149
EP - 150
JO - Experimental Dermatology
JF - Experimental Dermatology
SN - 0906-6705
IS - 2
ER -