Is SOD2 Ala16Val polymorphism associated with migraine with aura phenotype?

Raffaele Palmirotta, Piero Barbanti, Maria Laura De Marchis, Gabriella Egeo, Cinzia Aurilia, Luisa Fofi, Cristiano Ialongo, Maria Giovanna Valente, Patrizia Ferroni, David Della Morte, Fiorella Guadagni

Research output: Contribution to journalArticle

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Abstract

Several studies suggest a role of oxidative stress in the physiopathology of migraine, particularly in the form with aura. In a case-control study, we investigated the association between migraine and superoxide dismutase 1 (SOD1) and superoxide dismutase 2 (SOD2) genes in a cohort of 490 consecutive unrelated Caucasian migraineurs (migraine with aura [MwA], n=107; migraine without aura [MwoA], n=246; chronic migraine [CM], n=137) and 246 healthy controls recruited at our Headache and Pain Unit and stored in the Interinstitutional Multidisciplinary BioBank (BioBIM). Migraine phenotype was carefully detailed using face-to-face interviews. We examined polymorphisms of SOD1 gene (A/C substitution-rs2234694) and SOD2 gene (C/T transition-rs4880-Ala16Val). The rs4880 TT (Val/Val) genotype was associated (p=0.042) with the presence of unilateral cranial autonomic symptoms (UAs) in MwA patients. We also found a mild correlation between SOD2 rs4880 genotype and the type of acute migraine treatment (p=0.048) in MwA patients. Our findings suggest that SOD2 is a disease-modifier gene influencing oxidative mechanisms in MwA. These observations lead to the hypothesis that SOD2 polymorphism may cause a defective control of the oxidative phenomena linked to cortical spreading depression, the neurophysiological hallmark of migraine aura, causing an overstimulation of trigeminal neurons and UAs triggering. Antioxid. Redox Signal. 22, 275-279.

Original languageEnglish
Pages (from-to)275-279
Number of pages5
JournalAntioxidants and Redox Signaling
Volume22
Issue number3
DOIs
StatePublished - Jan 20 2015
Externally publishedYes

Fingerprint

Migraine with Aura
Polymorphism
Migraine Disorders
Phenotype
Genes
Superoxide Dismutase
Epilepsy
Genotype
Cortical Spreading Depression
Oxidative stress
Modifier Genes
Migraine without Aura
Neurons
Substitution reactions
Oxidation-Reduction
Headache
superoxide dismutase 2
Association reactions
Case-Control Studies
Oxidative Stress

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology
  • Physiology
  • Clinical Biochemistry

Cite this

Palmirotta, R., Barbanti, P., De Marchis, M. L., Egeo, G., Aurilia, C., Fofi, L., ... Guadagni, F. (2015). Is SOD2 Ala16Val polymorphism associated with migraine with aura phenotype? Antioxidants and Redox Signaling, 22(3), 275-279. https://doi.org/10.1089/ars.2014.6069

Is SOD2 Ala16Val polymorphism associated with migraine with aura phenotype? / Palmirotta, Raffaele; Barbanti, Piero; De Marchis, Maria Laura; Egeo, Gabriella; Aurilia, Cinzia; Fofi, Luisa; Ialongo, Cristiano; Valente, Maria Giovanna; Ferroni, Patrizia; Della Morte, David; Guadagni, Fiorella.

In: Antioxidants and Redox Signaling, Vol. 22, No. 3, 20.01.2015, p. 275-279.

Research output: Contribution to journalArticle

Palmirotta, R, Barbanti, P, De Marchis, ML, Egeo, G, Aurilia, C, Fofi, L, Ialongo, C, Valente, MG, Ferroni, P, Della Morte, D & Guadagni, F 2015, 'Is SOD2 Ala16Val polymorphism associated with migraine with aura phenotype?', Antioxidants and Redox Signaling, vol. 22, no. 3, pp. 275-279. https://doi.org/10.1089/ars.2014.6069
Palmirotta R, Barbanti P, De Marchis ML, Egeo G, Aurilia C, Fofi L et al. Is SOD2 Ala16Val polymorphism associated with migraine with aura phenotype? Antioxidants and Redox Signaling. 2015 Jan 20;22(3):275-279. https://doi.org/10.1089/ars.2014.6069
Palmirotta, Raffaele ; Barbanti, Piero ; De Marchis, Maria Laura ; Egeo, Gabriella ; Aurilia, Cinzia ; Fofi, Luisa ; Ialongo, Cristiano ; Valente, Maria Giovanna ; Ferroni, Patrizia ; Della Morte, David ; Guadagni, Fiorella. / Is SOD2 Ala16Val polymorphism associated with migraine with aura phenotype?. In: Antioxidants and Redox Signaling. 2015 ; Vol. 22, No. 3. pp. 275-279.
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