Is schizophrenia a syndrome of accelerated aging?

Brian Kirkpatrick, Erick Messias, Philip D Harvey, Emilio Fernandez-Egea, Christopher R. Bowie

Research output: Contribution to journalArticle

149 Citations (Scopus)

Abstract

Schizophrenia is associated with a number of anatomical and physiological abnormalities outside of the brain, as well as with a decrease in average life span estimated at 20% in the United States. Some studies suggest that this increased mortality is not entirely due to associated causes such as suicide and the use of psychotropic medications. In this article, in order to focus greater attention on the increased mortality associated with schizophrenia, we present a special case of the hypothesis that physiological abnormalities associated with schizophrenia make a contribution to the increased mortality of schizophrenia: specifically, the hypothesis that schizophrenia is a syndrome of accelerated aging. Evidence consistent with this hypothesis comes from several areas. The biological plausibility of the hypothesis is supported by the existence of established syndromes of accelerated aging and by the sharing of risk factors between schizophrenia and other age-related conditions. We propose methods for testing the hypothesis.

Original languageEnglish
Pages (from-to)1024-1032
Number of pages9
JournalSchizophrenia Bulletin
Volume34
Issue number6
DOIs
StatePublished - Nov 1 2008
Externally publishedYes

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Schizophrenia
Mortality
Suicide
Brain

Keywords

  • Aging
  • Epidemiology
  • Mortality
  • Progeria
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Kirkpatrick, B., Messias, E., Harvey, P. D., Fernandez-Egea, E., & Bowie, C. R. (2008). Is schizophrenia a syndrome of accelerated aging? Schizophrenia Bulletin, 34(6), 1024-1032. https://doi.org/10.1093/schbul/sbm140

Is schizophrenia a syndrome of accelerated aging? / Kirkpatrick, Brian; Messias, Erick; Harvey, Philip D; Fernandez-Egea, Emilio; Bowie, Christopher R.

In: Schizophrenia Bulletin, Vol. 34, No. 6, 01.11.2008, p. 1024-1032.

Research output: Contribution to journalArticle

Kirkpatrick, B, Messias, E, Harvey, PD, Fernandez-Egea, E & Bowie, CR 2008, 'Is schizophrenia a syndrome of accelerated aging?', Schizophrenia Bulletin, vol. 34, no. 6, pp. 1024-1032. https://doi.org/10.1093/schbul/sbm140
Kirkpatrick B, Messias E, Harvey PD, Fernandez-Egea E, Bowie CR. Is schizophrenia a syndrome of accelerated aging? Schizophrenia Bulletin. 2008 Nov 1;34(6):1024-1032. https://doi.org/10.1093/schbul/sbm140
Kirkpatrick, Brian ; Messias, Erick ; Harvey, Philip D ; Fernandez-Egea, Emilio ; Bowie, Christopher R. / Is schizophrenia a syndrome of accelerated aging?. In: Schizophrenia Bulletin. 2008 ; Vol. 34, No. 6. pp. 1024-1032.
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