Is Obstructive Sleep Apnea Associated with Progressive Glaucomatous Optic Neuropathy?

Swarup S. Swaminathan, Amitabha S. Bhakta, Wei Shi, William J Feuer, Alexandre Abreu, Alejandro D. Chediak, David Greenfield

Research output: Contribution to journalArticle

Abstract

Purpose:The purpose of this study was to evaluate the relationship between obstructive sleep apnea syndrome (OSAS) and glaucoma progression, and to examine the correlation between OSAS severity and rate of visual field (VF) loss.Methods:Patients with concurrent diagnoses of open-angle glaucoma and OSAS between 2010 and 2016 were identified. Enrollment criteria consisted of glaucomatous optic neuropathy and VF loss, ≥5 reliable VFs, ≥2 years of follow-up, and polysomnography (PSG) within 12 months of final VF. PSG parameters including apnea-hypopnea index (AHI) and oxygen saturation (SpO2) were collected. Eyes were classified as "progressors" or "nonprogressors" based upon event analysis using Glaucoma Progression Analysis criteria. Two-tailed t test comparisons were performed, and correlations between rates of VF loss and PSG parameters were assessed.Results:A total of 141 patients with OSAS and glaucoma were identified. Twenty-five patients (age 67.9±7.6 y) with OSAS (8 mild, 8 moderate, 9 severe) were enrolled. Eleven eyes (44%) were classified as progressors, and had more severe baseline VF loss (P=0.03). Progressors and nonprogressors had nonsignificantly different (P>0.05) age (69.9±8.7 vs. 66.4±6.6 y), follow-up (4.4±0.7 vs. 4.3±1.0 y), intraocular pressure (13.1±2.8 vs. 14.9±2.5 mm Hg), mean ocular perfusion pressure (49.7±5.5 vs. 48.8±9.0 mm Hg), AHI (31.3±18.6 vs. 26.4±24.0), body-mass index (27.8±5.5 vs. 28.8±5.6), and SpO2 (94.1±1.6% vs. 94.0±1.6%). AHI was not correlated with slopes of VF mean deviation (r, -0.271; P, 0.190) or pattern standard deviation (r, 0.211; P, 0.312), and no substantial increase in risk of progression was found with increase in AHI.Conclusions:This study does not support a relationship between OSAS and glaucomatous progression. No correlation was observed between OSAS severity and rate of VF loss.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalJournal of Glaucoma
Volume27
Issue number1
DOIs
StatePublished - Jan 1 2018

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Optic Nerve Diseases
Obstructive Sleep Apnea
Visual Fields
Apnea
Polysomnography
Glaucoma
Open Angle Glaucoma
Intraocular Pressure
Body Mass Index
Perfusion
Oxygen
Pressure

Keywords

  • glaucoma
  • hypopnea
  • obstructive sleep apnea syndrome
  • visual field progression

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Is Obstructive Sleep Apnea Associated with Progressive Glaucomatous Optic Neuropathy? / Swaminathan, Swarup S.; Bhakta, Amitabha S.; Shi, Wei; Feuer, William J; Abreu, Alexandre; Chediak, Alejandro D.; Greenfield, David.

In: Journal of Glaucoma, Vol. 27, No. 1, 01.01.2018, p. 1-6.

Research output: Contribution to journalArticle

Swaminathan, Swarup S. ; Bhakta, Amitabha S. ; Shi, Wei ; Feuer, William J ; Abreu, Alexandre ; Chediak, Alejandro D. ; Greenfield, David. / Is Obstructive Sleep Apnea Associated with Progressive Glaucomatous Optic Neuropathy?. In: Journal of Glaucoma. 2018 ; Vol. 27, No. 1. pp. 1-6.
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AU - Shi, Wei

AU - Feuer, William J

AU - Abreu, Alexandre

AU - Chediak, Alejandro D.

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N2 - Purpose:The purpose of this study was to evaluate the relationship between obstructive sleep apnea syndrome (OSAS) and glaucoma progression, and to examine the correlation between OSAS severity and rate of visual field (VF) loss.Methods:Patients with concurrent diagnoses of open-angle glaucoma and OSAS between 2010 and 2016 were identified. Enrollment criteria consisted of glaucomatous optic neuropathy and VF loss, ≥5 reliable VFs, ≥2 years of follow-up, and polysomnography (PSG) within 12 months of final VF. PSG parameters including apnea-hypopnea index (AHI) and oxygen saturation (SpO2) were collected. Eyes were classified as "progressors" or "nonprogressors" based upon event analysis using Glaucoma Progression Analysis criteria. Two-tailed t test comparisons were performed, and correlations between rates of VF loss and PSG parameters were assessed.Results:A total of 141 patients with OSAS and glaucoma were identified. Twenty-five patients (age 67.9±7.6 y) with OSAS (8 mild, 8 moderate, 9 severe) were enrolled. Eleven eyes (44%) were classified as progressors, and had more severe baseline VF loss (P=0.03). Progressors and nonprogressors had nonsignificantly different (P>0.05) age (69.9±8.7 vs. 66.4±6.6 y), follow-up (4.4±0.7 vs. 4.3±1.0 y), intraocular pressure (13.1±2.8 vs. 14.9±2.5 mm Hg), mean ocular perfusion pressure (49.7±5.5 vs. 48.8±9.0 mm Hg), AHI (31.3±18.6 vs. 26.4±24.0), body-mass index (27.8±5.5 vs. 28.8±5.6), and SpO2 (94.1±1.6% vs. 94.0±1.6%). AHI was not correlated with slopes of VF mean deviation (r, -0.271; P, 0.190) or pattern standard deviation (r, 0.211; P, 0.312), and no substantial increase in risk of progression was found with increase in AHI.Conclusions:This study does not support a relationship between OSAS and glaucomatous progression. No correlation was observed between OSAS severity and rate of VF loss.

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KW - glaucoma

KW - hypopnea

KW - obstructive sleep apnea syndrome

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