Abstract
The interactions between Mg2+ and Ca2+ and the total content of magnesium were studied in beta-cell-rich pancreatic islets from ob/ob mice. High concentrations of Mg2+ inhibited basal intracellular 45Ca net uptake as well as that stimulated by K+ depolarization or Na+ omission, suggesting that Ca2+ and Mg2+ can compete for both the voltage-dependent Ca2+ and the Na+ channels. The magnesium content of the islets was remarkably stable being affected only under extreme conditions. It is suggested that the physiological stimulation of insulin secretion does not depend on dynamic fluctuations of magnesium metabolism.
| Original language | English |
|---|---|
| Pages (from-to) | 1225-1228 |
| Number of pages | 4 |
| Journal | Acta Biologica et Medica Germanica |
| Volume | 41 |
| Issue number | 12 |
| State | Published - Dec 1 1982 |
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ASJC Scopus subject areas
- Medicine(all)
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Is Mg2+ important for the secretory function of the pancreatic beta-cells? / Bergsten, P.; Berggren, P. O.; Larsson, R.; Gylfe, E.
In: Acta Biologica et Medica Germanica, Vol. 41, No. 12, 01.12.1982, p. 1225-1228.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Is Mg2+ important for the secretory function of the pancreatic beta-cells?
AU - Bergsten, P.
AU - Berggren, P. O.
AU - Larsson, R.
AU - Gylfe, E.
PY - 1982/12/1
Y1 - 1982/12/1
N2 - The interactions between Mg2+ and Ca2+ and the total content of magnesium were studied in beta-cell-rich pancreatic islets from ob/ob mice. High concentrations of Mg2+ inhibited basal intracellular 45Ca net uptake as well as that stimulated by K+ depolarization or Na+ omission, suggesting that Ca2+ and Mg2+ can compete for both the voltage-dependent Ca2+ and the Na+ channels. The magnesium content of the islets was remarkably stable being affected only under extreme conditions. It is suggested that the physiological stimulation of insulin secretion does not depend on dynamic fluctuations of magnesium metabolism.
AB - The interactions between Mg2+ and Ca2+ and the total content of magnesium were studied in beta-cell-rich pancreatic islets from ob/ob mice. High concentrations of Mg2+ inhibited basal intracellular 45Ca net uptake as well as that stimulated by K+ depolarization or Na+ omission, suggesting that Ca2+ and Mg2+ can compete for both the voltage-dependent Ca2+ and the Na+ channels. The magnesium content of the islets was remarkably stable being affected only under extreme conditions. It is suggested that the physiological stimulation of insulin secretion does not depend on dynamic fluctuations of magnesium metabolism.
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UR - http://www.scopus.com/inward/citedby.url?scp=0020340588&partnerID=8YFLogxK
M3 - Article
C2 - 6765164
VL - 41
SP - 1225
EP - 1228
JO - Acta Biologica et Medica Germanica
JF - Acta Biologica et Medica Germanica
SN - 0001-5318
IS - 12
ER -