Is major depression a neurologic disorder with psychiatric symptoms?

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

In the last decade, multiple investigator groups have identified structural changes of various neuroanatomic structures in patients with idiopathic major depression and bipolar disorders. Using high-resolution MRI of the brain and functional neuroimaging studies (i.e., PET, SPECT), researchers have described decreases in the volume of hippocampal formation, amygdala, entorhinal cortex, various frontal lobe structures, and basal ganglia, in addition to abnormal cerebral blood flow and metabolic activity in these structures as well as in thalamic nuclei. Similar structural and functional changes have been identified in patients with depression associated with a variety of neurologic disorders (i.e., stroke, Parkinson's disease, epilepsy, Alzheimer's dementia). In addition, recent data have shown that depression is a risk factor for the development of several neurologic disorders, including epilepsy, stroke, and Parkinson's disease and bears a negative impact on the course and outcome of most neurologic disorders. This article reviews these data and provides evidence that major depressive and bipolar disorders may in fact be neurologic disorders with psychiatric symptoms.

Original languageEnglish (US)
Pages (from-to)636-644
Number of pages9
JournalEpilepsy and Behavior
Volume5
Issue number5
DOIs
StatePublished - Oct 2004
Externally publishedYes

Fingerprint

Nervous System Diseases
Psychiatry
Depression
Bipolar Disorder
Parkinson Disease
Epilepsy
Cerebrovascular Circulation
Stroke
Research Personnel
Thalamic Nuclei
Entorhinal Cortex
Functional Neuroimaging
Major Depressive Disorder
Frontal Lobe
Amygdala
Basal Ganglia
Single-Photon Emission-Computed Tomography
Hippocampus
Alzheimer Disease
Brain

Keywords

  • Amygdala
  • Basal ganglia
  • Hippocampal atrophy
  • Magnetic resonance imaging (MRI)
  • Poststroke depression
  • Prefrontal cortex
  • Volumetric measurements

ASJC Scopus subject areas

  • Clinical Neurology
  • Behavioral Neuroscience
  • Neurology

Cite this

Is major depression a neurologic disorder with psychiatric symptoms? / Kanner, Andres M.

In: Epilepsy and Behavior, Vol. 5, No. 5, 10.2004, p. 636-644.

Research output: Contribution to journalArticle

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