Is it relevant to screen young women hospitalized in psychiatric department for neuropsychiatric systemic lupus erythematosus (NPSLE)? A prospective study of 100 psychiatric inpatients

Alexandra Audemard-Verger, Elizabeth Comby, Clément Nathou, Audrey Sultan, Mathieu Frémont, Aurélie Baldolli, Louis Simon Trumier, Vincent Marzloff, Brigitte Le Mauff, Jennifer Manuzak, Sonia Dollfus, Boris Bienvenu

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

On the basis that diagnosis of neuropsychiatric systemic lupus erythematosus (NPSLE) is sometimes difficult and systemic lupus erythematosus (SLE) can present with isolated psychiatric symptoms, we initiated a survey in a psychiatric department to screen for NPSLE in young female inpatients. We prospectively studied consecutive young female patients referred to the department of psychiatry. Antinuclear antibodies (ANA), anti-deoxyribonucleic acid (DNA), and antiextractable soluble nuclear antigens (ENA) in the serum of patients were screened. In case of positive anti-DNA or anti-ENA, the patient was referred to the department of internal medicine. One hundred patients were enrolled, mean age 33.1±8.4 years. Most patients presented underlying psychiatric disorders: depression (46%), schizophrenia (13%), anxiety disorder (6%), and personality disorder (10%). A quarter of the cohort did not display underlying psychiatric disorders before hospitalization. Positive ANA ?1:160 were found in 32 of the 100 patients tested (32%). No patients presented anti-DNA antibodies. One patient had positive anti-sjogrën's syndrome related antigen A (SSA), but did not present any features of SLE or Sjögren syndrome. Thus, systematic screening of SLE is not relevant in young women hospitalized in psychiatric department. However, clinicians should keep in mind that SLE can present with pure psychiatric symptoms.

Original languageEnglish (US)
Article numbere5288
JournalMedicine (United States)
Volume95
Issue number47
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

Fingerprint

Central Nervous System Lupus Vasculitis
Psychiatry
Inpatients
Prospective Studies
Systemic Lupus Erythematosus
Antinuclear Antibodies
DNA
Nuclear Antigens
Personality Disorders
Internal Medicine
Anxiety Disorders
Schizophrenia
Hospitalization
Depression
Antigens

Keywords

  • Mental illness
  • Neuropsychiatric systemic lupus erythematosus
  • Psychiatric disorder
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Is it relevant to screen young women hospitalized in psychiatric department for neuropsychiatric systemic lupus erythematosus (NPSLE)? A prospective study of 100 psychiatric inpatients. / Audemard-Verger, Alexandra; Comby, Elizabeth; Nathou, Clément; Sultan, Audrey; Frémont, Mathieu; Baldolli, Aurélie; Trumier, Louis Simon; Marzloff, Vincent; Le Mauff, Brigitte; Manuzak, Jennifer; Dollfus, Sonia; Bienvenu, Boris.

In: Medicine (United States), Vol. 95, No. 47, e5288, 01.01.2016.

Research output: Contribution to journalArticle

Audemard-Verger, A, Comby, E, Nathou, C, Sultan, A, Frémont, M, Baldolli, A, Trumier, LS, Marzloff, V, Le Mauff, B, Manuzak, J, Dollfus, S & Bienvenu, B 2016, 'Is it relevant to screen young women hospitalized in psychiatric department for neuropsychiatric systemic lupus erythematosus (NPSLE)? A prospective study of 100 psychiatric inpatients', Medicine (United States), vol. 95, no. 47, e5288. https://doi.org/10.1097/MD.0000000000005288
Audemard-Verger, Alexandra ; Comby, Elizabeth ; Nathou, Clément ; Sultan, Audrey ; Frémont, Mathieu ; Baldolli, Aurélie ; Trumier, Louis Simon ; Marzloff, Vincent ; Le Mauff, Brigitte ; Manuzak, Jennifer ; Dollfus, Sonia ; Bienvenu, Boris. / Is it relevant to screen young women hospitalized in psychiatric department for neuropsychiatric systemic lupus erythematosus (NPSLE)? A prospective study of 100 psychiatric inpatients. In: Medicine (United States). 2016 ; Vol. 95, No. 47.
@article{9aabc725737e4ba0a281458232f77f4d,
title = "Is it relevant to screen young women hospitalized in psychiatric department for neuropsychiatric systemic lupus erythematosus (NPSLE)? A prospective study of 100 psychiatric inpatients",
abstract = "On the basis that diagnosis of neuropsychiatric systemic lupus erythematosus (NPSLE) is sometimes difficult and systemic lupus erythematosus (SLE) can present with isolated psychiatric symptoms, we initiated a survey in a psychiatric department to screen for NPSLE in young female inpatients. We prospectively studied consecutive young female patients referred to the department of psychiatry. Antinuclear antibodies (ANA), anti-deoxyribonucleic acid (DNA), and antiextractable soluble nuclear antigens (ENA) in the serum of patients were screened. In case of positive anti-DNA or anti-ENA, the patient was referred to the department of internal medicine. One hundred patients were enrolled, mean age 33.1±8.4 years. Most patients presented underlying psychiatric disorders: depression (46{\%}), schizophrenia (13{\%}), anxiety disorder (6{\%}), and personality disorder (10{\%}). A quarter of the cohort did not display underlying psychiatric disorders before hospitalization. Positive ANA ?1:160 were found in 32 of the 100 patients tested (32{\%}). No patients presented anti-DNA antibodies. One patient had positive anti-sjogr{\"e}n's syndrome related antigen A (SSA), but did not present any features of SLE or Sj{\"o}gren syndrome. Thus, systematic screening of SLE is not relevant in young women hospitalized in psychiatric department. However, clinicians should keep in mind that SLE can present with pure psychiatric symptoms.",
keywords = "Mental illness, Neuropsychiatric systemic lupus erythematosus, Psychiatric disorder, Systemic lupus erythematosus",
author = "Alexandra Audemard-Verger and Elizabeth Comby and Cl{\'e}ment Nathou and Audrey Sultan and Mathieu Fr{\'e}mont and Aur{\'e}lie Baldolli and Trumier, {Louis Simon} and Vincent Marzloff and {Le Mauff}, Brigitte and Jennifer Manuzak and Sonia Dollfus and Boris Bienvenu",
year = "2016",
month = "1",
day = "1",
doi = "10.1097/MD.0000000000005288",
language = "English (US)",
volume = "95",
journal = "Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries",
issn = "0025-7974",
publisher = "Lippincott Williams and Wilkins",
number = "47",

}

TY - JOUR

T1 - Is it relevant to screen young women hospitalized in psychiatric department for neuropsychiatric systemic lupus erythematosus (NPSLE)? A prospective study of 100 psychiatric inpatients

AU - Audemard-Verger, Alexandra

AU - Comby, Elizabeth

AU - Nathou, Clément

AU - Sultan, Audrey

AU - Frémont, Mathieu

AU - Baldolli, Aurélie

AU - Trumier, Louis Simon

AU - Marzloff, Vincent

AU - Le Mauff, Brigitte

AU - Manuzak, Jennifer

AU - Dollfus, Sonia

AU - Bienvenu, Boris

PY - 2016/1/1

Y1 - 2016/1/1

N2 - On the basis that diagnosis of neuropsychiatric systemic lupus erythematosus (NPSLE) is sometimes difficult and systemic lupus erythematosus (SLE) can present with isolated psychiatric symptoms, we initiated a survey in a psychiatric department to screen for NPSLE in young female inpatients. We prospectively studied consecutive young female patients referred to the department of psychiatry. Antinuclear antibodies (ANA), anti-deoxyribonucleic acid (DNA), and antiextractable soluble nuclear antigens (ENA) in the serum of patients were screened. In case of positive anti-DNA or anti-ENA, the patient was referred to the department of internal medicine. One hundred patients were enrolled, mean age 33.1±8.4 years. Most patients presented underlying psychiatric disorders: depression (46%), schizophrenia (13%), anxiety disorder (6%), and personality disorder (10%). A quarter of the cohort did not display underlying psychiatric disorders before hospitalization. Positive ANA ?1:160 were found in 32 of the 100 patients tested (32%). No patients presented anti-DNA antibodies. One patient had positive anti-sjogrën's syndrome related antigen A (SSA), but did not present any features of SLE or Sjögren syndrome. Thus, systematic screening of SLE is not relevant in young women hospitalized in psychiatric department. However, clinicians should keep in mind that SLE can present with pure psychiatric symptoms.

AB - On the basis that diagnosis of neuropsychiatric systemic lupus erythematosus (NPSLE) is sometimes difficult and systemic lupus erythematosus (SLE) can present with isolated psychiatric symptoms, we initiated a survey in a psychiatric department to screen for NPSLE in young female inpatients. We prospectively studied consecutive young female patients referred to the department of psychiatry. Antinuclear antibodies (ANA), anti-deoxyribonucleic acid (DNA), and antiextractable soluble nuclear antigens (ENA) in the serum of patients were screened. In case of positive anti-DNA or anti-ENA, the patient was referred to the department of internal medicine. One hundred patients were enrolled, mean age 33.1±8.4 years. Most patients presented underlying psychiatric disorders: depression (46%), schizophrenia (13%), anxiety disorder (6%), and personality disorder (10%). A quarter of the cohort did not display underlying psychiatric disorders before hospitalization. Positive ANA ?1:160 were found in 32 of the 100 patients tested (32%). No patients presented anti-DNA antibodies. One patient had positive anti-sjogrën's syndrome related antigen A (SSA), but did not present any features of SLE or Sjögren syndrome. Thus, systematic screening of SLE is not relevant in young women hospitalized in psychiatric department. However, clinicians should keep in mind that SLE can present with pure psychiatric symptoms.

KW - Mental illness

KW - Neuropsychiatric systemic lupus erythematosus

KW - Psychiatric disorder

KW - Systemic lupus erythematosus

UR - http://www.scopus.com/inward/record.url?scp=85005958928&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85005958928&partnerID=8YFLogxK

U2 - 10.1097/MD.0000000000005288

DO - 10.1097/MD.0000000000005288

M3 - Article

C2 - 27893665

AN - SCOPUS:85005958928

VL - 95

JO - Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries

JF - Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries

SN - 0025-7974

IS - 47

M1 - e5288

ER -