Cholelithiasis is a very common illness in Europe and America. Most of the gallstones found are made by crystals of cholesterol. Cholesterol is a normal constituent of bile. It is insoluble in water but can be solubilized in a micellar system where bile salts and lecithin are present. When relative excess of cholesterol occurs this excess precipitates and forms the stones. Different kinds of medical treatment for these types of gallstones were tested in the past after Antonio Vallisnieri (1661-1730) found that there are substances capable to dissolve cholesterol. None of these treatments were successful, but in the last decade new attempts were made The results of recent studies showed that chenodeoxycholic acid, phenobarbital, d thyroxine and other substances can dissolve cholesterol gallstones due to the property of changing the composition of the bile because they increase the bile salt and lecithin pool, diminishing simultaneously the relative concentration of cholesterol, and making the bile unsaturated or micellar. A summary of the results obtained using these drugs and a critical evaluation of the proposed treatments was made.
|Number of pages||8|
|Journal||Prensa Medica Argentina|
|State||Published - Dec 1 1973|
ASJC Scopus subject areas